Mesenchymal Stem Cells: Characteristics, Sources, and Mechanisms of Action

被引：80
作者：
Stewart, Matthew C. [1 ]
Stewart, Allison A. [1 ]
机构：
[1] Univ Illinois, Dept Vet Clin Med, Coll Vet Med, Urbana, IL 61802 USA
来源：
VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE | 2011年 / 27卷 / 02期
关键词：
Mesenchymal stem cell; Differentiation; Osteogenesis; Chondrogenesis; HUMAN BONE-MARROW; UMBILICAL-CORD BLOOD; IN-VITRO CHONDROGENESIS; IMPROVE HEART FUNCTION; ADIPOSE-TISSUE; STROMAL CELLS; ARTICULAR-CARTILAGE; SELF-RENEWAL; PERIPHERAL-BLOOD; PROGENITOR CELLS;
D O I：
10.1016/j.cveq.2011.06.004
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
This article provides an overview of mesenchymal stem cell (MSC) biology. In the first section, the characteristics that are routinely used to define MSCs-adherence, proliferation, multi-lineage potential, and "cluster of differentiation" marker profiles-are discussed. In the second section, the major tissues and body fluids that are used as sources for equine MSCs are presented, along with the comparative biologic activities of MSCs from specific locations. Finally, the current understanding of the mechanisms by which MSCs influence repair and regeneration are discussed, with an emphasis on the clinical importance of MSC trophic activities.
引用
收藏
页码：243 / +
页数：20
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