Bioactive microbial metabolites Part 33.: Bacilosarcins A and B, novel bioactive isocoumarins with unusual heterocyclic cores from the marine-derived bacterium Bacillus subtilis

被引：62

作者：

Azumi, Miwa ^{[1
]}

Ogawa, Ken-ichi ^{[1
]}

Fujita, Tsuyoshi ^{[2
]}

Takeshita, Michinori ^{[3
]}

Yoshida, Ryuji ^{[4
]}

Furumai, Tamotsu ^{[1
]}

Igarashi, Yasuhiro ^{[1
]}

机构：

[1] Toyama Prefectural Univ, Biotechnol Res Ctr, Toyama 9390398, Japan

[2] Suntory Inst Bioorgan Res, Osaka 6188503, Japan

[3] Saga Univ, Fac Sci & Engn, Dept Chem & Appl Chem, Saga 8408502, Japan

[4] Toyama Prefectural Univ, Coll Technol, Toyama 9390398, Japan

来源：

TETRAHEDRON | 2008年 / 64卷 / 27期

关键词：

bacilosarcin; Bacillus subtilis; amicoumacin;

D O I：

10.1016/j.tet.2008.04.076

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel isocoumarins, bacilosarcins A (1) and B (2) were isolated from a culture broth of the marine-derived bacterium Bacillus subtilis TP-B0611. The Structures and absolute configurations of 1 and 2 were determined on the basis of spectroscopic analyses and chemical conversions. Compound 1 possesses an unprecedented 3-oxa-6,9-diazabicyclo[3.3.1]nonane ring system while 2 has a 2-hydroxymorpholine moiety that is rare in nature. These compounds showed growth inhibition against barnyard millet. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：6420 / 6425

页数：6

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