Hybrid lipid oligonucleotide conjugates: synthesis, self-assemblies and biomedical applications

被引：99
|
作者：
Patwa, Amit [1 ,2 ]
Gissot, Arnaud [1 ,2 ]
Bestel, Isabelle [1 ,2 ]
Barthelemy, Philippe [1 ,2 ]
机构：
[1] Univ Bordeaux Segalen, F-33076 Bordeaux, France
[2] INSERM, U869, F-33076 Bordeaux, France
来源：
CHEMICAL SOCIETY REVIEWS | 2011年 / 40卷 / 12期
关键词：
SOLID-PHASE SYNTHESIS; HELIX FORMING OLIGONUCLEOTIDES; DIRECT CNS DELIVERY; IN-VIVO DELIVERY; NUCLEIC-ACIDS; HYBRIDIZATION PROPERTIES; ANCHORED DNA; MISMATCH DISCRIMINATION; PHOSPHOLIPID-MEMBRANES; LIPOPHILIC SIRNAS;
D O I：
10.1039/c1cs15038c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Hybrid lipid oligonucleotide conjugates are finding more and more biotechnological applications. This short critical review highlights their synthesis, supramolecular organization as well as their applications in the field of biotechnology (111 references).
引用
收藏
页码：5844 / 5854
页数：11
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