A Novel Prognostic Ferroptosis-Related Long Noncoding RNA Signature in Clear Cell Renal Cell Carcinoma

被引:9
作者
Bai, Zhixun [1 ]
Zhao, Yongchao [2 ]
Yang, Xiaomin [3 ]
Wang, Linglu [4 ]
Yin, Xianhua [1 ]
Chen, Yue [5 ]
Lu, Jing [5 ]
机构
[1] Zunyi Med Univ, Affiliated Hosp 2, Dept Nephrol, Zunyi, Guizhou, Peoples R China
[2] Zunyi Med Univ, Affiliated Hosp, Dept Cardiol, Zunyi, Guizhou, Peoples R China
[3] First Peoples Hosp Xiangtan City, Dept Nephrol, Xiangtan, Peoples R China
[4] Zunyi Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Zunyi, Guizhou, Peoples R China
[5] Zunyi Med & Pharmaceut Coll, Dept Clin, Zunyi, Guizhou, Peoples R China
关键词
COMPREHENSIVE ANALYSIS; IRON; PREDICTS; SURVIVAL; SYSTEM; FORM;
D O I
10.1155/2022/6304824
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Clear cell renal cell carcinoma (ccRCC) is the most common primary malignancy of renal cancer in adults. Ferroptosis is critically associated with the prognosis of ccRCC. However, knowledge of long noncoding RNA- (lncRNA-) related ferroptosis that affects the prognosis of ccRCC is still insufficient. Using the LASSO regression, we created a risk model based on differentially expressed ferroptosis-related lncRNAs (FRLRS) in ccRCC. The analysis of Kaplan-Meier for survival, area under the curve (AUC) for diagnosis, nomogram for predicting overall survival, and gene expression for immune checkpoints were performed based on the screened independent prognostic factors. Nine lncRNAs were found to be associated with ccRCC prognosis. Furthermore, the prognostic AUC of the FRLRS signature was 0.78, demonstrating its usefulness in predicting ccRCC prognosis. The lncRNA risk model outperformed the standard clinical variables in predicting ccRCC prognosis. Finally, The Cancer Genome Atlas revealed that T cell functions, such as cytolytic activity, human leukocyte antigen activity, inflammation regulation, and type II interferon response coordination, are significantly different between two different risk levels of ccRCC. Immune checkpoints were also expressed differently in programmed cell death 1 receptor, inducible T cell costimulator, cytotoxic T-lymphocyte antigen-4, and leukocyte-associated immunoglobulin-like receptor 1. The nine FRLRS signature models may affect the prognosis of ccRCC.
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页数:16
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