Toward noninvasive brain stimulation 2.0 in Alzheimer's disease

被引：68

作者：

Menardi, Arianna ^{[1
,2
,3
]}

Rossi, Simone ^{[4
]}

Koch, Giacomo ^{[5
]}

Hampel, Harald ^{[6
]}

Vergallo, Andrea ^{[6
]}

Nitsche, Michael A. ^{[7
,8
]}

Stern, Yaakov ^{[9
,10
,11
]}

Borroni, Barbara ^{[12
]}

Cappa, Stefano F. ^{[13
,14
]}

Cotelli, Maria ^{[15
]}

Ruffini, Giulio ^{[16
]}

El-Fakhri, Georges ^{[17
]}

Rossini, Paolo M. ^{[18
]}

Dickerson, Brad ^{[19
,20
]}

Antal, Andrea ^{[21
]}

Babiloni, Claudio ^{[22
,23
]}

Lefaucheur, Jean-Pascal ^{[24
,25
]}

Dubois, Bruno ^{[6
,26
,27
]}

Deco, Gustavo ^{[28
,29
]}

Ziemann, Ulf ^{[30
,31
]}

Pascual-Leone, Alvaro ^{[32
,33
,34
,35
]}

Santarnecchi, Emiliano ^{[1
]}

机构：

[1] Harvard Med Sch, Gordon Ctr Med Imaging, Massachusetts Gen Hosp, Dept Radiol,Precis Neurosci & Neuromodulat Progra, Boston, MA 02115 USA

[2] Univ Padua, Padova Neurosci Ctr, Padua, PD, Italy

[3] Univ Padua, Dept Neurosci, Padua, PD, Italy

[4] Univ Siena, Dept Med Surg & Neurosci, Neurol & Clin Neurophysiol Sect, Siena Brain Invest & Neuromodulat Lab, Siena, Italy

[5] Santa Lucia Fdn IRCCS, Dept Behav & Clin Neurol, Noninvas Brain Stimulat Unit, Rome, Italy

[6] Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Alzheimer Precis Med APM,GRC 21, Blvd Hop, F-75013 Paris, France

[7] Leibniz Res Ctr Working Environm & Human Factors, Dept Psychol & Neurosiences, Dortmund, Germany

[8] Univ Med Hosp Bergmannsheil, Dept Neurol, Bochum, Germany

[9] Columbia Univ Coll Phys & Surg, Dept Neurol, Psychiat & Taub Inst, 630 W 168th St, New York, NY 10032 USA

[10] Columbia Univ Coll Phys & Surg, Dept Psychiat, 630 W 168th St, New York, NY 10032 USA

[11] Columbia Univ Coll Phys & Surg, Taub Inst, 630 W 168th St, New York, NY 10032 USA

[12] Univ Brescia, Dept Clin & Expt Sci, Neurol Unit, Brescia, Italy

[13] Inst Adv Study IUSS Pavia, Pavia, Italy

[14] IRCCS Mondino Fdn, Pavia, Italy

[15] IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Neuropsychol Unit, Brescia, Italy

[16] Neuroelect Corp, 210 Broadway, Cambridge, MA 02139 USA

[17] Harvard Med Sch, Gordon Ctr Med Imaging, Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02115 USA

[18] IRCCS San Raffaele Pisana, Dept Neurosci & Neurorehabil, Rome, Italy

[19] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Frontotemporal Disorders Unit, Boston, MA 02115 USA

[20] Harvard Med Sch, Alzheimers Dis Res Ctr, Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02115 USA

[21] Georg August Univ, Univ Med Ctr Gottingen, Dept Clin Neurophysiol, Gottingen, Germany

[22] Sapienza Univ Rome, Dept Physiol & Pharmacol Erspamer, Rome, Italy

[23] San Raffaele Cassino, Cassino, Italy

[24] Paris Est Creteil Univ, Fac Med, ENT Team, EA4391, Creteil, France

[25] Henri Mondor Hosp, Assistance Publ Hop Paris, Clin Neurophysiol Unit, Dept Physiol, Creteil, France

[26] CNRS UMR 7225, INSERM U1127, Brain & Spine Inst ICM, Blvd Hop, Paris, France

[27] Hop La Pitie Salpetriere, AP HP, Dept Neurol, Inst Memory & Alzheimers Dis IM2A, Blvd Hop, Paris, France

[28] Univ Pompeu Fabra, Ctr Brain & Cognit, Dept Technol & Informat, Carrer Tanger 122-140, Barcelona 08018, Spain

[29] Univ Barcelona, Inst Catalana Recerca & Estudis Avancats, Passeig Lluis Co 23, Barcelona 08010, Spain

[30] Eberhard Karls Univ Tubingen, Dept Neurol & Stroke, Tubingen, Germany

[31] Eberhard Karls Univ Tubingen, Hertie Inst Clin Brain Res, Tubingen, Germany

[32] Harvard Med Sch, Dept Neurol, Boston, MA 02115 USA

[33] Hebrew Senior Life, Hinda & Arthur Marcus Inst Aging Res, Boston, MA USA

[34] Hebrew Senior Life, Ctr Memory Hlth, Boston, MA USA

[35] Univ Autonoma Barcelona, Guttmann Brain Hlth Inst, Inst Guttmann, Barcelona, Spain

来源：

AGEING RESEARCH REVIEWS | 2022年 / 75卷

关键词：

Alzheimer's disease; Noninvasive brain stimulation; Transcranial magnetic stimulation; Transcranial electrical stimulation; Precision medicine; TRANSCRANIAL MAGNETIC STIMULATION; MILD COGNITIVE IMPAIRMENT; DOUBLE-BLIND; SHORT-TERM; CORTICAL EXCITABILITY; ENHANCES MEMORY; THETA; NETWORK; PLASTICITY; OSCILLATIONS;

D O I：

10.1016/j.arr.2021.101555

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Noninvasive brain stimulation techniques (NiBS) have gathered substantial interest in the study of dementia, considered their possible role in help defining diagnostic biomarkers of altered neural activity for early disease detection and monitoring of its pathophysiological course, as well as for their therapeutic potential of boosting residual cognitive functions. Nevertheless, current approaches suffer from some limitations. In this study, we review and discuss experimental NiBS applications that might help improve the efficacy of future NiBS uses in Alzheimer's Disease (AD), including perturbation-based biomarkers for early diagnosis and disease tracking, solutions to enhance synchronization of oscillatory electroencephalographic activity across brain networks, enhancement of sleep-related memory consolidation, image-guided stimulation for connectome control, protocols targeting interneuron pathology and protein clearance, and finally hybrid-brain models for in-silico modeling of AD pathology and personalized target selection. The present work aims to stress the importance of multidisciplinary, translational, model-driven interventions for precision medicine approaches in AD.

引用

页数：17

共 155 条

[1] Gamma Entrainment: Impact on Neurocircuits, Glia, and Therapeutic Opportunities [J].

Adaikkan, Chinnakkaruppan ;

Tsai, Li-Huei .

TRENDS IN NEUROSCIENCES, 2020, 43 (01) :24-41

[2] Effects of low versus high frequencies of repetitive transcranial magnetic stimulation on cognitive function and cortical excitability in Alzheimer's dementia [J].

Ahmed, Mohamed A. ;

Darwish, Esam S. ;

Khedr, Eman M. ;

El Serogy, Yasser M. ;

Ali, Anwer M. .

JOURNAL OF NEUROLOGY, 2012, 259 (01) :83-92

[3] 2021 Alzheimer's disease facts and figures [J].

不详 .

ALZHEIMERS & DEMENTIA, 2021, 17 (03) :327-406

[4] Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines [J].

Antal, A. ;

Alekseichuk, I. ;

Bikson, M. ;

Brockmoeller, J. ;

Brunoni, A. R. ;

Chen, R. ;

Cohen, L. G. ;

Dowthwaite, G. ;

Ellrich, J. ;

Floeel, A. ;

Fregni, F. ;

George, M. S. ;

Hamilton, R. ;

Haueisen, J. ;

Herrmann, C. S. ;

Hummel, F. C. ;

Lefaucheur, J. P. ;

Liebetanz, D. ;

Loo, C. K. ;

McCaig, C. D. ;

Miniussi, C. ;

Miranda, P. C. ;

Moliadze, V. ;

Nitsche, M. A. ;

Nowak, R. ;

Padberg, F. ;

Pascual-Leone, A. ;

Poppendieck, W. ;

Priori, A. ;

Rossi, S. ;

Rossini, P. M. ;

Rothwell, J. ;

Rueger, M. A. ;

Ruffini, G. ;

Schellhorn, K. ;

Siebner, H. R. ;

Ugawa, Y. ;

Wexler, A. ;

Ziemann, U. ;

Hallett, M. ;

Paulus, W. .

CLINICAL NEUROPHYSIOLOGY, 2017, 128 (09) :1774-1809

[5] Transcranial Alternating Current and Random Noise Stimulation: Possible Mechanisms [J].

Antal, Andrea ;

Herrmann, Christoph S. .

NEURAL PLASTICITY, 2016, 2016

[6] Hippocampal, Amygdala, and Neocortical Synchronization of Theta Rhythms is Related to an Immediate Recall During Rey Auditory Verbal Learning Test [J].

Babiloni, Claudio ;

Vecchio, Fabrizio ;

Mirabella, Giovanni ;

Buttiglione, Maura ;

Sebastiano, Fabio ;

Picardi, Angelo ;

Di Gennaro, Giancarlo ;

Quarato, Pier P. ;

Grammaldo, Liliana G. ;

Buffo, Paola ;

Esposito, Vincenzo ;

Manfredi, Mario ;

Cantore, Giampaolo ;

Eusebi, Fabrizio .

HUMAN BRAIN MAPPING, 2009, 30 (07) :2077-2089

[7] Laminar recordings in frontal cortex suggest distinct layers for maintenance and control of working memory [J].

Bastos, Andre M. ;

Loonis, Roman ;

Kornblith, Simon ;

Lundqvist, Mikael ;

Miller, Earl K. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (05) :1117-1122

[8] Classification Accuracy of Transcranial Magnetic Stimulation for the Diagnosis of Neurodegenerative Dementias [J].

Benussi, Alberto ;

Grassi, Mario ;

Palluzzi, Fernando ;

Koch, Giacomo ;

Di Lazzaro, Vincenzo ;

Nardone, Raffaele ;

Cantoni, Valentina ;

Dell'Era, Valentina ;

Premi, Enrico ;

Martorana, Alessandro ;

di Lorenzo, Francesco ;

Bonni, Sonia ;

Ranieri, Federico ;

Capone, Fioravante ;

Musumeci, Gabriella ;

Cotelli, Maria Sofia ;

Padovani, Alessandro ;

Borroni, Barbara .

ANNALS OF NEUROLOGY, 2020, 87 (03) :394-404

[9] The impact of transcranial magnetic stimulation on diagnostic confidence in patients with Alzheimer disease [J].

Benussi, Alberto ;

Alberici, Antonella ;

Ferrari, Clarissa ;

Cantoni, Valentina ;

Dell'Era, Valentina ;

Turrone, Rosanna ;

Cotelli, Maria Sofia ;

Binetti, Giuliano ;

Paghera, Barbara ;

Koch, Giacomo ;

Padovani, Alessandro ;

Borroni, Barbara .

ALZHEIMERS RESEARCH & THERAPY, 2018, 10

[10] Transcranial magnetic stimulation distinguishes Alzheimer disease from frontotemporal dementia [J].

Benussi, Alberto ;

Di Lorenzo, Francesco ;

Dell'Era, Valentina ;

Cosseddu, Maura ;

Alberici, Antonella ;

Caratozzolo, Salvatore ;

Cotelli, Maria Sofia ;

Micheli, Anna ;

Rozzini, Luca ;

Depari, Alessandro ;

Flammini, Alessandra ;

Ponzo, Viviana ;

Martorana, Alessandro ;

Caltagirone, Carlo ;

Padovani, Alessandro ;

Koch, Giacomo ;

Borroni, Barbara .

NEUROLOGY, 2017, 89 (07) :665-672

← 1 2 3 4 5 6 7 8 9 10 →