Voltage-Gated P/Q-Type Calcium Channel Antibodies Associated With Cerebellar Degeneration

被引：4
作者：
Spiciarich, Mary C. [1 ]
Moshe, Solomon L. [1 ,2 ,3 ,4 ]
机构：
[1] Montefiore Med Ctr, Saul R Korey Dept Neurol, 111 E 210th St, Bronx, NY 10467 USA
[2] Albert Einstein Coll Med, Dominick P Purpura Dept Neurosci, Bronx, NY 10467 USA
[3] Montefiore Med Ctr, 111 E 210th St, Bronx, NY 10467 USA
[4] Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10467 USA
来源：
PEDIATRIC NEUROLOGY | 2016年 / 62卷
关键词：
paraneoplastic; cerebellar degeneration; voltage-gated calcium channel antibodies; child; female; PEDIATRIC HODGKIN-DISEASE; EATON-MYASTHENIC-SYNDROME; LUNG-CANCER; ATAXIA; CHILD;
D O I：
10.1016/j.pediatrneurol.2016.06.004
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
BACKGROUND: Paraneoplastic cerebellar degeneration is a rare neurological condition characterized by diffuse cerebellar dysfunction and magnetic resonance imaging evidence of progressive cerebellar atrophy. It has been associated with several autoantibodies and malignancies in adults. To date, only six cases have been described in male children. PATIENT DESCRIPTION: We describe an eight-year-old girl with a prodrome of abdominal pain and vomiting followed by acute onset diplopia, dysarthria, dysmetria, and ataxia. She was found to have cerebellar degeneration in association with P/Q-type calcium channel antibodies. CONCLUSION: This is the first child with documented paraneoplastic cerebellar degeneration in association with P/Q-type calcium channel antibodies.
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页码：43 / 46
页数：4
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