The interfacial behavior of designed ankyrin repeat proteins

被引：6
|
作者：
Mitropoulos, V. [1 ]
Windhab, E. J. [1 ]
Fischer, P. [1 ]
机构：
[1] ETH, CH-8092 Zurich, Switzerland
来源：
SOFT MATTER | 2011年 / 7卷 / 17期
关键词：
DIFFUSION-COEFFICIENTS; MOLECULAR-DYNAMICS; LIQUID INTERFACES; ADSORPTION; RHEOLOGY; KINETICS; LAYERS; FILMS;
D O I：
10.1039/c1sm05256j
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Proteins adsorb spontaneously at virtually any interface between the aqueous solution they are diluted in and a gas, solid, or liquid phase. In this study we correlate the mechanical properties of a protein adsorption layer at the air/liquid interface to the structure, stability and surface activity of a set of recombinant proteins called designed ankyrin repeat proteins (DARPins). Two designed proteins with the same folding pattern but different lengths are applied to show that the viscoelastic properties of the protein adsorption film can be adjusted by changing the stability of the molecules themselves.
引用
收藏
页码：7612 / 7615
页数：4
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