Association of TGF-β1-509C/T,+869T/C, and+915G/C polymorphisms with periodontitis susceptibility

ObjectivesTo investigate the potential association of TGF-1 -509C/T (rs1800469), +869T/C (rs1800470), and +915G/C (rs1800471) polymorphisms with susceptibility to periodontitis. Materials and MethodsSeveral electronic databases were searched for eligible articles. Odds ratios (ORs) along with their 95% confidence intervals (CIs) were calculated to assess the strength of relationship between the TGF-1 polymorphisms and periodontitis risk. ResultsEleven studies were searched without any language restriction. Pooled estimates showed that TGF-1 -509C/T polymorphism was associated with decreased risk of periodontitis. Subgroup analysis revealed that -509C/T T allele was associated with decreased risk of chronic periodontitis (CP) in Asians (T allele vs C allele: OR=0.81, 95% CI=0.69-0.97, P-heterogeneity=0.25). Furthermore, the +915G/C CC genotype might be associated with elevated risk of CP in Caucasians (CC vs GG: OR=9.14, 95% CI=1.01-82.50, P-heterogeneity=0.49). Concerning +869T/C polymorphism, no evidence of significant association was identified. ConclusionThis meta-analysis suggested that TGF-1 -509C/T T allele was associated with decreased risk of CP in Asians, while +915G/C CC genotype might contribute to increased CP risk in Caucasians. Replication studies of our results in independent large populations are necessary to validate this association in diverse populations.