Neurocognitive Effects of Chemotherapy for Colorectal Cancer: A Systematic Review and a Meta-Analysis of 11 Studies

被引：11

作者：

Hwang, Soo Young ^{[1
]}

Kim, Kwanghyun ^{[2
]}

Ha, Byeonggwan ^{[1
]}

Lee, Dongkyu ^{[1
]}

Kim, Seonung ^{[1
]}

Ryu, Seongjun ^{[1
]}

Yang, Jisu ^{[3
]}

Jung, Sun Jae ^{[2
,4
]}

机构：

[1] Yonsei Univ, Coll Med, Seoul, South Korea

[2] Yonsei Univ, Coll Med, Dept Prevent Med, 50 Yonsei Ro, Seoul 03722, South Korea

[3] Yonsei Univ, Dept Publ Hlth, Seoul, South Korea

[4] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

来源：

CANCER RESEARCH AND TREATMENT | 2021年 / 53卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

Cognitive dysfunction; Colorectal neoplasms; Drug therapy; Meta-analysis; QUALITY-OF-LIFE; INDUCED COGNITIVE IMPAIRMENT; BREAST-CANCER; ADJUVANT CHEMOTHERAPY; WOMEN; OXALIPLATIN; DOMAINS; IMPACT; ADULTS; OLDER;

D O I：

10.4143/crt.2020.1191

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose Chemotherapy-related cognitive impairment (CRCI) is a controversial concept not much explored on colorectal cancer Materials and Methods We identified 11 prospective studies: eight studies on 696 colorectal cancer patients who received chemotherapy and three studies on 346 rectal cancer patients who received neoadjuvant chemoradiotherapy. Standardized mean differences (SMDs) of neuropsychological test results and the cognitive quality-of-life scale were calculated using random effect models. A meta-regression was conducted to investigate the association between mean study population age and effect sizes. Results The association between chemotherapy and cognitive impairment was not clear in colorectal cancer patients (SMD, 0.003; 95% confidence interval, -0.080 to 0.086). However, a meta-regression showed that older patients are more vulnerable to CRCI than younger patients (beta=-0.016, p < 0.001). Conclusion Chemotherapy has an overall positive negligible effect size on the cognitive function of colorectal patients. Age is a significant moderator of CRCI.

引用

页码：1134 / 1147

页数：14