Molecular Imaging of Hypoxia: Strategies for Probe Design and Application

被引：38
作者：
Apte, Sandeep [1 ]
Chin, Frederick T. [2 ]
Graves, Edward E. [1 ]
机构：
[1] Stanford Univ, Sch Med, MIPS, Dept Radiat Oncol, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, MIPS, Dept Radiol, Stanford, CA 94305 USA
来源：
CURRENT ORGANIC SYNTHESIS | 2011年 / 8卷 / 04期
关键词：
Hypoxia; Cancer; Molecular Imaging; Radiosynthesis; Fluorination; Fluorine-18; Copper-64; HIF-1; Carbonic Anhydrase IX; Positron Emission Tomography; Fluorescence; Single Photon Emission Computed Tomography; CARBONIC-ANHYDRASE INHIBITORS; GROWTH-FACTOR EXPRESSION; RENAL-CELL CARCINOMA; TUMOR HYPOXIA; MONOCLONAL-ANTIBODY; INDUCIBLE FACTOR-1-ALPHA; AUTOMATED RADIOSYNTHESIS; UNFAVORABLE PROGNOSIS; FLUORESCENT MARKERS; CANCER;
D O I：
10.2174/157017911796117179
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Tumor hypoxia is a negative prognostic factor and its precise imaging is of great relevance to therapy planning. The present review summarizes various strategies of probe design for imaging hypoxia with a variety of techniques such as PET, SPECT and fluorescence imaging. Synthesis of some important probes that are used for preclinical and clinical imaging and their mechanism of binding in hypoxia are also discussed.
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页码：593 / 603
页数：11
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