Expression of self-antigen in the thymus: A little goes a long way

被引:26
作者
Anderson, AC [1 ]
Kuchroo, VK [1 ]
机构
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Dis, Boston, MA 02115 USA
关键词
MYELIN BASIC-PROTEIN; PROMISCUOUS GENE-EXPRESSION; REGULATORY T-CELLS; AUTOIMMUNE-DISEASE; EPITHELIAL-CELLS; HIGH-FREQUENCY; TOLERANCE; FOXP3; REPERTOIRE; MOUSE;
D O I
10.1084/jem.20031803
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:1627 / 1629
页数:3
相关论文
共 27 条
[1]   High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: Mechanisms of selection of the self-reactive repertoire [J].
Anderson, AC ;
Nicholson, LB ;
Legge, KL ;
Turchin, V ;
Zaghouani, H ;
Kuchroo, VK .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (05) :761-770
[2]   Projection of an immunological self shadow within the thymus by the aire protein [J].
Anderson, MS ;
Venanzi, ES ;
Klein, L ;
Chen, ZB ;
Berzins, SP ;
Turley, SJ ;
von Boehmer, H ;
Bronson, R ;
Dierich, A ;
Benoist, C ;
Mathis, D .
SCIENCE, 2002, 298 (5597) :1395-1401
[3]   Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation [J].
Asano, M ;
Toda, M ;
Sakaguchi, N ;
Sakaguchi, S .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :387-396
[4]   An immunologically privileged retinal antigen elicits tolerance: Major role for central selection mechanisms [J].
Avichezer, D ;
Grajewski, RS ;
Chan, CC ;
Mattapallil, MJ ;
Silver, PB ;
Raber, JA ;
Liou, GI ;
Wiggert, B ;
Lewis, GM ;
Donoso, LA ;
Caspi, RR .
JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (11) :1665-1676
[5]  
CarrascoMarin E, 1996, J IMMUNOL, V156, P450
[6]  
Derbinski J, 2001, NAT IMMUNOL, V2, P1032, DOI 10.1038/ni723
[7]   Thymus and tolerance. Is regulation the major function of the thymus? [J].
Durkin, HG ;
Waksman, BH .
IMMUNOLOGICAL REVIEWS, 2001, 182 :33-57
[8]  
Egwuagu CE, 1997, J IMMUNOL, V159, P3109
[9]   Foxp3 Programs the Development and Function of CD4+CD25+ Regulatory T Cells (Reprinted from vol 4, pg 330-336, 2003) [J].
Fontenot, Jason D. ;
Gavin, Marc A. ;
Rudensky, Alexander Y. .
JOURNAL OF IMMUNOLOGY, 2017, 198 (03) :986-992
[10]   THYMIC EXPRESSION OF THE GOLLI-MYELIN BASIC-PROTEIN GENE IN THE SJL/J MOUSE [J].
FRITZ, RB ;
KALVAKOLANU, I .
JOURNAL OF NEUROIMMUNOLOGY, 1995, 57 (1-2) :93-99