Antimicrobial Properties of Some Bis(Iminoacenaphthene (BIAN)-Supported N-Heterocyclic Carbene Complexes of Silver and Gold

被引：33

作者：

Butorac, Rachel R. ^{[1
]}

Al-Deyab, Salem S. ^{[2
]}

Cowley, Alan H. ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Chem & Biochem, Univ Stn, Austin, TX 78712 USA

[2] King Saud Univ, Dept Chem, Coll Sci, Riyadh 11451, Saudi Arabia

来源：

MOLECULES | 2011年 / 16卷 / 03期

基金：

美国国家科学基金会;

关键词：

N-heterocyclic carbene; gold; silver; antimicrobial; MINIMUM INHIBITORY CONCENTRATIONS; IMIDAZOLIUM; LIGANDS; SALTS;

D O I：

10.3390/molecules16032285

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The AgCl, AgOAc, AuCl, and AuOAc complexes of the new bis(imino) acenaphthene(BIAN)-supported N-heterocyclic carbene ligand and the precursor imidazolium salt have been investigated with respect to their antimicrobial activities against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Psudomonas aeruginosa. The most active antimicrobial is the precursor imidazolium salt, which has a minimum inhibitory concentration (MIC) value of < 40 mu g/mL. The MIC values for the silver complexes IPr(BIAN) AgCl and IPr(BIAN) AgOAc against Gram-positive S. aureus are comparable to that for AgNO3, while those against Gram-negative E. coli and P. aeroginosa are significantly larger. Similar behavior was evident for the gold acetate complex IPr(BIAN) AuOAc. However, in the case of the gold chloride analogue, the MIC values are virtually identical for both the Gram-positive and the Gram-negative bacteria.

引用

页码：2285 / 2292

页数：8

共 14 条

[1] Determination of minimum inhibitory concentrations [J].

Andrews, JM .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2001, 48 :5-16

[2] Targeting the mitochondrial cell death pathway with gold compounds [J].

Barnard, Peter J. ;

Berners-Price, Susan J. .

COORDINATION CHEMISTRY REVIEWS, 2007, 251 (13-14) :1889-1902

[3] Remarkable substituent effects on antimicrobial activities of 1,3-diorganylimidazolidinium salts [J].

Çetinkaya, E ;

Denizci, A ;

Özdemir, I ;

Öztürk, HT ;

Karaboz, I ;

Çetinkaya, B .

JOURNAL OF CHEMOTHERAPY, 2002, 14 (03) :241-245

[4] Synthesis and antimicrobial properties of imidazolium and pyrrolidinonium salts [J].

Demberelnyamba, D ;

Kim, KS ;

Choi, SJ ;

Park, SY ;

Lee, H ;

Kim, CJ ;

Yoo, ID .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (05) :853-857

[5] Recent developments in the coordination chemistry of bis(imino)acenaphthene (BIAN) ligands with s- and p-block elements [J].

Hill, Nicholas J. ;

Vargas-Baca, Ignacio ;

Cowley, Alan H. .

DALTON TRANSACTIONS, 2009, (02) :240-253

[6] The Medicinal Applications of Imidazolium Carbene-Metal Complexes [J].

Hindi, Khadijah M. ;

Panzner, Matthew J. ;

Tessier, Claire A. ;

Cannon, Carolyn L. ;

Youngs, Wiley J. .

CHEMICAL REVIEWS, 2009, 109 (08) :3859-3884

[7] Synthetic and antimicrobial studies on new gold(I) complexes of imidazolidin-2-ylidenes [J].

Özdemir, I ;

Denizci, A ;

Öztürk, HT ;

Çetinkaya, B .

APPLIED ORGANOMETALLIC CHEMISTRY, 2004, 18 (07) :318-322

[8] Gold(I) Complexes of N-Heterocyclic Carbene Ligands Containing Benzimidazole: Synthesis and Antimicrobial Activity [J].

Ozdemir, Ilknur ;

Temelli, Nazan ;

Gunal, Selami ;

Demir, Serpil .

MOLECULES, 2010, 15 (04) :2203-2210

[9] Novel benzyl-substituted N-heterocyclic carbene-silver acetate complexes: synthesis, cytotoxicity and antibacterial studies [J].

Patil, Siddappa ;

Deally, Anthony ;

Gleeson, Brendan ;

Mueller-Bunz, Helge ;

Paradisi, Francesca ;

Tacke, Matthias .

METALLOMICS, 2011, 3 (01) :74-88

[10] 3-alkylthiomethyl-1-ethylimidazolium chlorides. Correlation between critical micelle concentrations and minimum inhibitory concentrations [J].

Pernak, J ;

Skrzypczak, A .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1996, 31 (11) :901-903

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