Mechanisms of disease: Gene silencing in cancer in association with promoter hypermethylation

被引：2574
作者：
Herman, JG [1 ]
Baylin, SB
机构：
[1] Johns Hopkins Med Inst, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21205 USA
[2] Johns Hopkins Med Inst, Dept Oncol, Baltimore, MD 21205 USA
[3] Johns Hopkins Med Inst, Dept Med, Baltimore, MD 21205 USA
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2003年 / 349卷 / 21期
关键词：
D O I：
10.1056/NEJMra023075
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
[No abstract available]
引用
收藏
页码：2042 / 2054
页数：13
相关论文
共 131 条
[1]   Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer [J].
Ahrendt, SA ;
Chow, JT ;
Xu, LH ;
Yang, SC ;
Eisenberger, CF ;
Esteller, M ;
Herman, JG ;
Wu, L ;
Decker, PA ;
Jen, J ;
Sidransky, D .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (04) :332-339
[2]  
Ahuja N, 1998, CANCER RES, V58, P5489
[3]  
Antequera F., 1993, Experientia Supplementum (Basel), V64, P169
[4]   Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene [J].
Bachman, KE ;
Park, BH ;
Rhee, I ;
Rajagopalan, H ;
Herman, JG ;
Baylin, SB ;
Kinzler, KW ;
Vogelstein, B .
CANCER CELL, 2003, 3 (01) :89-95
[5]   Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin [J].
Bachman, KE ;
Rountree, MR ;
Baylin, SB .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (34) :32282-32287
[6]  
Bachman KE, 1999, CANCER RES, V59, P798
[7]   Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer [J].
Baylin, SB ;
Esteller, M ;
Rountree, MR ;
Bachman, KE ;
Schuebel, K ;
Herman, JG .
HUMAN MOLECULAR GENETICS, 2001, 10 (07) :687-692
[8]   DNA hypermethylation in tumorigenesis - epigenetics joins genetics [J].
Baylin, SB ;
Herman, JG .
TRENDS IN GENETICS, 2000, 16 (04) :168-174
[9]   Aberrant methylation of p16INK4a is an early event in lung cancer and a potential biomarker for early diagnosis [J].
Belinsky, SA ;
Nikula, KJ ;
Palmisano, WA ;
Michels, R ;
Saccomanno, G ;
Gabrielson, E ;
Baylin, SB ;
Herman, JG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (20) :11891-11896
[10]  
Bestor TH, 1998, CIBA F SYMP, V214, P187
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