A Signal-to-Cutoff Ratio in the Abbott Architect HIV Ag/Ab Combo Assay That Predicts Subsequent Confirmation of HIV-1 Infection in a Low-Prevalence Setting

被引：25

作者：

Jensen, Tomas Ostergaard ^{[1
,2
,3
]}

Robertson, Peter ^{[4
]}

Whybin, Ross ^{[4
]}

Chambers, Ian ^{[5
]}

Lahra, Monica ^{[4
]}

Rawlinson, William ^{[4
]}

Post, Jeffrey John ^{[1
,2
,3
]}

机构：

[1] Prince Wales Hosp, Dept Infect Dis, Sydney, NSW, Australia

[2] Prince Wales Hosp, Albion Ctr, Sydney, NSW, Australia

[3] Univ New S Wales, Prince Wales Clin Sch, Sydney, NSW, Australia

[4] Prince Wales Hosp, Serol & Virol Div, South Eastern Area Lab Serv, Sydney, NSW, Australia

[5] Douglass Hanly Moir Pathol, Sydney, NSW, Australia

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2015年 / 53卷 / 05期

关键词：

P24; ANTIGEN; PERFORMANCE EVALUATION; DIAGNOSIS; ANTIBODY; TESTS;

D O I：

10.1128/JCM.03583-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A rapid diagnosis is considered important in HIV care. In 138,911 testing episodes with the Abbott Architect HIV Ag/Ab Combo assay (3,705 reactive samples), a signal-to-cutoff ratio of >151.17 had a positive predictive value of 100% and a sensitivity of 67.4% for the detection of subsequently confirmed HIV infection. We suggest that results higher than this signal-to-cutoff ratio threshold may be reported to clinicians before the completion of confirmatory testing.

引用

页码：1709 / 1711

页数：3

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