Prenatal Environmental Exposure to Persistent Organic Pollutants and Reproductive Hormone Profile and Pubertal Development in Dutch Adolescents

被引:5
作者
Berghuis, Sietske A. [1 ]
Bos, Arend F. [1 ]
Groen, Henk [2 ]
de Jong, Wilhelmina H. A. [3 ]
Kobold, Anneke C. Muller [3 ]
Wagenmakers-Huizinga, Lucie [3 ]
Sauer, Pieter J. J. [1 ]
Bocca, Gianni [4 ]
机构
[1] Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, Div Neonatol,Dept Pediat, NL-9713 GZ Groningen, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9713 GZ Groningen, Netherlands
[3] Univ Groningen, Univ Med Ctr Groningen, Dept Lab Med, NL-9713 GZ Groningen, Netherlands
[4] Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, Div Endocrinol,Dept Pediat, NL-9713 GZ Groningen, Netherlands
关键词
adolescence; adolescent; chemical exposure; endocrine disruptor; persistent organic pollutant; polychlorinated biphenyl; prenatal exposure; pubertal development; reproductive hormone; testosterone; POLYCHLORINATED BIPHENYL EXPOSURE; IN-UTERO; ENDOCRINE DISRUPTORS; SERUM; BOYS; CHEMICALS; PATTERN; MOTHERS; DIOXINS; PCBS;
D O I
10.3390/ijerph19159423
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Persistent organic pollutants (POPs), such as polychlorinated biphenyls (PCBs), may interfere with hormonal processes. Knowledge about the effects of prenatal exposure to PCBs and their hydroxylated metabolites (OH-PCBs) on pubertal development is limited. Therefore, the aim of the current study was to determine whether prenatal environmental PCB and OH-PCB exposure are associated with reproductive hormone levels and pubertal characteristics in 13- to 15-year-old children. In this Dutch observational cohort study, 194 mother-infant pairs were included (1998-2002). Maternal pregnancy serum levels of PCBs, OH-PCBs, and other POPs were measured. At follow-up (2014-2016), we measured serum or plasma levels of reproductive hormones in their children. We assessed Tanner stages and testicular volume (by clinician or standardized self-assessment), and participants completed questionnaires on pubertal onset. In total, 101 adolescents (14.4 +/- 0.8 years; 53.7% of invited) participated, and 55 were boys. In boys, higher prenatal PCB levels were associated with higher testosterone levels, higher pubic hair stage, larger testicular volume, and younger age at onset of growth spurt and voice break. In girls, higher prenatal PCB levels were associated with higher stages for breast development. In conclusion, higher prenatal PCB exposure could be associated with more advanced pubertal development in 13- to 15-year-old children.
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页数:16
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