A transdiagnostic perspective of constructs underlying obsessive-compulsive and related disorders: An international Delphi consensus study

被引：12

作者：

Fontenelle, Leonardo F. ^{[1
,2
,3
]}

Oldenhof, Erin ^{[1
]}

Moreira-de-Oliveira, Maria Eduarda ^{[2
,3
]}

Abramowitz, Jonathan S. ^{[4
]}

Antony, Martin M. ^{[5
]}

Cath, Danielle ^{[6
,7
,8
]}

Carter, Adrian ^{[1
]}

Dougherty, Darin ^{[9
,10
,11
,12
]}

Ferrao, Ygor A. ^{[13
]}

Figee, Martijn ^{[14
,15
]}

Harrison, Ben J. ^{[16
]}

Hoexter, Marcelo Q. ^{[17
]}

Kwon, Jun Soo ^{[18
]}

Kueelz, Anne K. ^{[19
]}

Lazaro, Luisa ^{[20
]}

Lochner, Christine ^{[21
]}

Marazziti, Donatella ^{[22
]}

Mataix-Cols, David ^{[23
]}

McKay, Dean ^{[24
]}

Miguel, Euripedes C. ^{[17
]}

Morein-Zamir, Sharon ^{[25
]}

Moritz, Steffen ^{[26
]}

Nestadt, Gerald ^{[27
]}

O'Connor, Kieron ^{[28
]}

Pallanti, Stefano ^{[29
,30
]}

Purdon, Christine ^{[31
]}

Rauch, Scott ^{[10
,12
]}

Richter, Peggy ^{[32
,33
]}

Rotge, Jean-Yves ^{[34
]}

Shavitt, Roseli G. ^{[17
]}

Soriano-Mas, Carles ^{[35
,36
,37
]}

Starcevic, Vladan ^{[38
]}

Stein, Dan J. ^{[39
,40
]}

Steketee, Gail ^{[41
]}

Storch, Eric A. ^{[42
]}

Taylor, Steven ^{[43
]}

van den Heuvel, Odile A. ^{[44
,45
,46
]}

Veale, David ^{[47
]}

Woods, Douglas W. ^{[48
,49
]}

Verdejo-Garcia, Antonio ^{[1
]}

Yucel, Murat ^{[1
]}

机构：

[1] Monash Univ, Sch Psychol Sci, Turner Inst Brain & Mental Hlth, Room 1461,770 Blackburn Rd, Melbourne, Vic 3800, Australia

[2] DOr Sao Luiz Network, DOr Inst Res & Educ, Rio De Janeiro, Brazil

[3] Univ Fed Rio de Janeiro, Inst Psychiat, Obsess Compuls & Anxiety Spectrum Res Program, Rio De Janeiro, Brazil

[4] Univ North Carolina, Dept Psychol & Neurosci, Chapel Hill, NC 27515 USA

[5] Ryerson Univ, Dept Psychol, Toronto, ON, Canada

[6] Univ Groningen, RGOc, UMC Groningen, Groningen, Netherlands

[7] Univ Groningen, Dept Psychiat, UMC Groningen, Groningen, Netherlands

[8] Mental Hlth Serv Drenthe, Dept Specialized Trainings, Assen, Netherlands

[9] Massachusetts Gen Hosp, Div Neurotherapeut, Boston, MA 02114 USA

[10] McLean Hosp, Obsess Compuls Disorder Inst, 115 Mill St, Belmont, MA 02178 USA

[11] Massachusetts Gen Hosp, Obsess Compuls & Related Disorders Program, Boston, MA 02114 USA

[12] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA

[13] Fed Univ Hlth Sci Porto Alegre UFCSPA, Dept Psychiat, Porto Alegre, RS, Brazil

[14] Univ Amsterdam, Amsterdam Univ, Dept Psychiat, Med Ctr, Amsterdam, Netherlands

[15] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA

[16] Univ Melbourne, Melbourne Neuropsychiat Ctr, Dept Psychiat, Melbourne, Vic, Australia

[17] Univ Sao Paulo, Fac Med, Dept Psychiat, Sao Paulo, Brazil

[18] Seoul Natl Univ, Coll Med, Dept Psychiat, Seoul, South Korea

[19] Univ Freiburg, Fac Med, Med Ctr, Dept Psychiat & Psychotherapy, Freiburg, Germany

[20] Univ Barcelona, Hosp Clin Barcelona, Dept Child & Adolescent Psychiat & Psychol, IDIBAPS,CIBERSAM, Barcelona, Spain

[21] Stellenbosch Univ, Dept Psychiat, SU UCT MRC Unit Risk & Resilience Mental Disorder, Stellenbosch, South Africa

[22] Univ Pisa, Sect Psychiat, Dipartimento Med Clin & Sperimentale, Pisa, Italy

[23] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

[24] Fordham Univ, Dept Psychol, Bronx, NY 10458 USA

[25] Anglia Ruskin Univ, Sch Psychol & Sports Sci, Cambridge, England

[26] Univ Med Ctr Hamburg Eppendorf, Dept Psychiat & Psychotherapy, Hamburg, Germany

[27] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA

[28] Univ Mt Real, Mt Real Univ Inst Mental Hlth, Res Ctr, Montreal, PQ, Canada

[29] Stanford Univ, Med Ctr, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA

[30] Univ Florence, Inst Neurosci, Florence, Italy

[31] Univ Waterloo, Dept Psychol, Waterloo, ON, Canada

[32] Sunnybrook Hlth Care Sci, Anxiety Disorders Ctr, Toronto, ON, Canada

[33] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[34] Sorbonne Univ, AP HP, ICM IHU, Inserm U 127,CNRS UMR 7225,Dept Psychiat,Inst Ce, Paris, France

[35] Mental Hlth Networking Biomed Res Ctr CIBERSAM, Bellvitge Biomed Res Inst, Dept Psychiat, IDIBELL, Barcelona, Spain

[36] Mental Hlth Networking Biomed Res Ctr CIBERSAM, Bellvitge Biomed Res Inst, Dept Psychobiol & Methodol Hlth Sci, IDIBELL, Barcelona, Spain

[37] Univ Autonoma Barcelona, Barcelona, Spain

[38] Univ Sydney, Nepean Hosp, Fac Med & Hlth, Sydney Med Sch,Dept Psychiat,Nepean Clin Sch, Sydney, NSW, Australia

[39] Univ Cape Town, Dept Psychiat, Cape Town, South Africa

[40] Univ Cape Town, MRC Unit Risk & Resilience Mental Disorders, Cape Town, South Africa

[41] Boston Univ, Sch Social Work, Boston, MA 02215 USA

[42] Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA

[43] Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada

[44] Vrije Univ, Dept Psychiat, Amsterdam Neurosci, Amsterdam UMC, Amsterdam, Netherlands

[45] Vrije Univ, Dept Anat & Neurosci, Amsterdam Neurosci, Amsterdam UMC, Amsterdam, Netherlands

[46] Haukeland Hosp, Bergen Ctr Brain Plastic, Bergen, Norway

[47] South London & Maudsley NHS Fdn Trust, Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England

[48] Texas A&M Univ, Dept Psychol & Brain Sci, College Stn, TX USA

[49] Marquette Univ, Dept Psychol, Milwaukee, WI 53233 USA

来源：

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY | 2020年 / 54卷 / 07期

基金：

美国国家卫生研究院; 英国医学研究理事会; 澳大利亚研究理事会;

关键词：

Obsessive-compulsive and related disorders; Research Domain Criteria; habit; cognitive control; compulsivity; IMPULSE CONTROL DISORDERS; EXPERT CONSENSUS; ENDOPHENOTYPE; ANXIETY; MODEL; INHIBITION; CRITERIA;

D O I：

10.1177/0004867420912327

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: The Research Domain Criteria seeks to bridge knowledge from neuroscience with clinical practice by promoting research into valid neurocognitive phenotypes and dimensions, irrespective of symptoms and diagnoses as currently conceptualized. While the Research Domain Criteria offers a vision of future research and practice, its 39 functional constructs need refinement to better target new phenotyping efforts. This study aimed to determine which Research Domain Criteria constructs are most relevant to understanding obsessive-compulsive and related disorders, based on a consensus between experts in the field of obsessive-compulsive and related disorders. Methods: Based on a modified Delphi method, 46 experts were recruited from Australia, Africa, Asia, Europe and the Americas. Over three rounds, experts had the opportunity to review their opinion in light of feedback from the previous round, which included how their response compared to other experts and a summary of comments given. Results: Thirty-four experts completed round one, of whom 28 (82%) completed round two and 24 (71%) completed round three. At the final round, four constructs were endorsed by > 75% of experts as 'primary constructs' and therefore central to understanding obsessive-compulsive and related disorders. Of these constructs, one came from the Positive Valence System (Habit), two from the Cognitive Control System (Response Selection/Inhibition and Performance Monitoring) and the final construct was an additional item suggested by experts (Compulsivity). Conclusion: This study identified four Research Domain Criteria constructs that, according to experts, cut across different obsessive-compulsive and related disorders. These constructs represent key areas for future investigation, and may have potential implications for clinical practice in terms of diagnostic processes and therapeutic management of obsessive-compulsive and related disorders.

引用

页码：719 / 731

页数：13

共 55 条

[1] The cognitive neuropsychology of obsessive-compulsive disorder: A critical review [J].

Abramovitch, Amitai ;

Cooperman, Allison .

JOURNAL OF OBSESSIVE-COMPULSIVE AND RELATED DISORDERS, 2015, 5 :24-36

[2] Stability of response characteristics of a Delphi panel: Application of bootstrap data expansion [J].

Akins R.B. ;

Tolson H. ;

Cole B.R. .

BMC Medical Research Methodology, 5 (1)

[3]

American Psychiatric Association, 2013, DIAGNOSTIC STAT MANU, V5, DOI 10.1176/appi.books.9780890425596

[4]

Andersen NB, 1981, SCANDINAVIAN J BEHAV, V10, P21

[5] Improving the Delphi process: Lessons from social psychological research [J].

Bolger, Fergus ;

Wright, George .

TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE, 2011, 78 (09) :1500-1513

[6]

Braun V., 2006, Qualitative Research in Psychology, V3, P77, DOI [10.1191/1478088706qp063oa, DOI 10.1191/1478088706QP063OA, DOI 10.1080/10875549.2021.1929659]

[7] Using the research domain criteria (RDoC) to conceptualize impulsivity and compulsivity in relation to addiction [J].

Brooks, Samantha J. ;

Lochner, Christine ;

Shoptaw, Steve ;

Stein, Dan J. .

BRAIN RESEARCH IN ADDICTION, 2017, 235 :177-218

[8] Phenomenology of Obsessive-Compulsive Disorder: A Methodologically Structured Overview [J].

Buergy, Martin .

PSYCHOPATHOLOGY, 2019, 52 (03) :174-183

[9] Increased error-related brain activity in youth with obsessive-compulsive disorder and other anxiety disorders [J].

Carrasco, Melisa ;

Hong, Christina ;

Nienhuis, Jenna K. ;

Harbin, Shannon M. ;

Fitzgerald, Kate D. ;

Gehring, William J. ;

Hanna, Gregory L. .

NEUROSCIENCE LETTERS, 2013, 541 :214-218

[10] Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives [J].

Chamberlain, Samuel R. ;

Menzies, Lara ;

Hampshire, Adam ;

Suckling, John ;

Fineberg, Naomi A. ;

del Campo, Natalia ;

Aitken, Mike ;

Craig, Kevin ;

Owen, Adrian M. ;

Bullmore, Edward T. ;

Robbins, Trevor W. ;

Sahakian, Barbara J. .

SCIENCE, 2008, 321 (5887) :421-422

← 1 2 3 4 5 6 →