High-Voltage Electrical Pulses in Oncology: Irreversible Electroporation, Electrochemotherapy, Gene Electrotransfer, Electrofusion, and Electroimmunotherapy

被引：277

作者：

Geboers, Bart ^{[1
]}

Scheffer, Hester J. ^{[1
]}

Graybill, Philip M. ^{[4
]}

Ruarus, Alette H. ^{[1
]}

Nieuwenhuizen, Sanne ^{[1
]}

Puijk, Robbert S. ^{[1
]}

van den Tol, Petrousjka M. ^{[2
]}

Davalos, Rafael, V ^{[4
]}

Rubinsky, Boris ^{[5
,6
]}

de Gruijl, Tanja D. ^{[3
]}

Miklavcic, Damijan ^{[7
]}

Meijerink, Martijn R. ^{[1
]}

机构：

[1] Univ Amsterdam, Med Ctr, Dept Radiol & Nucl Med, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands

[2] Univ Amsterdam, Med Ctr, Dept Surg, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands

[3] Univ Amsterdam, Med Ctr, Dept Med Oncol, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands

[4] Wake Forest Univ, Dept Biomed Engn & Mech, Bioelectromech Syst Lab, Virginia Tech, Blacksburg, VA USA

[5] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA

[6] Univ Calif Berkeley, Dept Mech Engn, Berkeley, CA 94720 USA

[7] Univ Ljubljana, Fac Elect Engn, Ljubljana, Slovenia

来源：

RADIOLOGY | 2020年 / 295卷 / 02期

关键词：

ADVANCED PANCREATIC-CANCER; PERCUTANEOUS RADIOFREQUENCY ABLATION; SINGLE-INSTITUTION EXPERIENCE; COLORECTAL LIVER METASTASES; LONG-TERM SURVIVAL; HEPATOCELLULAR-CARCINOMA; DENDRITIC CELLS; HEPATIC-TUMORS; SAFETY; EFFICACY;

D O I：

10.1148/radiol.2020192190

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

This review summarizes the use of high-voltage electrical pulses (HVEPs) in clinical oncology to treat solid tumors with irreversible electroporation (IRE) and electrochemotherapy (ECT). HVEPs increase the membrane permeability of cells, a phenomenon known as electroporation. Unlike alternative ablative therapies, electroporation does not affect the structural integrity of surrounding tissue, thereby enabling tumors in the vicinity of vital structures to be treated. IRE uses HVEPs to cause cell death by inducing membrane disruption, and it is primarily used as a radical ablative therapy in the treatment of soft-tissue tumors in the liver, kidney, prostate, and pancreas. ECT uses HVEPs to transiently increase membrane permeability, enhancing cellular cytotoxic drug uptake in tumors. IRE and ECT show immunogenic effects that could be augmented when combined with immunomodulatory drugs, a combination therapy the authors term electroimmunotherapy. Additional electroporation-based technologies that may reach clinical importance, such as gene electrotransfer, electrofusion, and electroimmunotherapy, are concisely reviewed. HVEPs represent a substantial advancement in cancer research, and continued improvement and implementation of these presented technologies will require close collaboration between engineers, interventional radiologists, medical oncologists, and immuno-oncologists. (C) RSNA, 2020

引用

页码：254 / 272

页数：19

共 136 条

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