ADAMs: focus on the protease domain

被引：407
作者：
Black, RA
White, JM
机构：
[1] Immunex Corp, Seattle, WA 98101 USA
[2] Univ Virginia, Hlth Sci Ctr, Dept Cell Biol, Charlottesville, VA 22908 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 05期
关键词：
D O I：
10.1016/S0955-0674(98)80042-2
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
ADAMs are proteins containing a disintegrin and metalloproteinase domain. Several important insights were provided in the past year regarding ADAM metalloproteinases. ADAM 10 was implicated in the Notch signaling pathway. ADAM 17 was shown to be the long sought after tumor necrosis factor-alpha convertase and the crystal structure of its metalloproteinase domain was determined.
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页码：654 / 659
页数：6
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