Overview and meta-analysis of randomised trials of amiodarone in chronic heart failure

被引：31

作者：

Piepoli, M ^{[1
]}

Villani, GQ

Ponikowski, P

Wright, A

Flather, MD

Coats, AJS

机构：

[1] Royal Brompton Hosp, Dept Cardiac Med, London SW3 6LY, England

[2] Royal Brompton Hosp, Clin Trials & Evaluat Unit, London SW3 6LY, England

[3] Gen Hosp, Dept Cardiol, Piacenza, Italy

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 1998年 / 66卷 / 01期

关键词：

amiodarone; antiarrhythmic drugs; chronic heart failure; meta-analysis;

D O I：

10.1016/S0167-5273(98)00184-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Unlike other antiarrhythmic class I drugs, amiodarone showed in preliminary studies, benefits also in patients with left ventricular dysfunction. These positive results have induced the development of large randomised controlled studies: their results are reviewed and the controversial points are discussed. In a mete-analysis of randomised controlled trials the use of amiodarone in heart failure was associated with an approximate 20 to 25% reduction in deaths. However, amiodarone was also associated with a 120 to 124% increase in side effects. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：1 / 10

页数：10

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