Modulation of platelet-derived microparticles to adhesion and motility of human rheumatoid arthritis fibroblast-like synoviocytes

被引：22
作者：
Wang, Wenwen [1 ,2 ]
Liu, Jiahuan [1 ,2 ]
Yang, Binzhou [3 ]
Ma, Zhongshuang [4 ]
Liu, Guiping [1 ,2 ]
Shen, Weigan [1 ,5 ,6 ]
Zhang, Yu [1 ,2 ,5 ,6 ]
机构：
[1] Yangzhou Univ, Clin Med Coll, Yangzhou, Jiangsu, Peoples R China
[2] Yangzhou Univ, Sch Med, Yangzhou, Jiangsu, Peoples R China
[3] Southwest JiaoTong Univ, Coll Med, Peoples Hosp Chengdu 3, Chengdu, Peoples R China
[4] Yancheng Chengnan Hosp, Dept Rheumatol, Yancheng, Peoples R China
[5] Jiangsu Key Lab Integrated Tradit Chinese & Weste, Yangzhou, Jiangsu, Peoples R China
[6] Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Jiangsu, Peoples R China
来源：
PLOS ONE | 2017年 / 12卷 / 07期
关键词：
NF-KAPPA-B; SYNOVIAL FIBROBLASTS; DISEASE-ACTIVITY; ACTIVATION; PATHOGENESIS; INFLAMMATION; MMP-1; CELL;
D O I：
10.1371/journal.pone.0181003
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Platelet-derived microparticles (PMPs) are closely associated with disease activity in rheumatoid arthritis (RA) and contribute to the inflammatory process. Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) play important roles in the progression of joint destruction. The aim of this study is to demonstrate whether PMPs affect the adhesion and motility of RA-FLSs. Our data indicated that PMPs promoted migration, invasion and adhesion to extracellular matrix (ECM) of RA-FLSs. Further study showed that PMPs up-regulated the expression of matrix metalloproteinase-1 (MMP1) and increased the level of phosphorylation of NF-kappa B (p-NF-kappa B) and Erk (p-Erk) in RA-FLSs. These results suggest that PMPs promote RA-FLSs adhesion and motility presumably by increasing MMP1 via activating Erk-mediated NF-kappa B pathway.
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页数：12
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