Modulation of platelet-derived microparticles to adhesion and motility of human rheumatoid arthritis fibroblast-like synoviocytes

被引：22

作者：

Wang, Wenwen ^{[1
,2
]}

Liu, Jiahuan ^{[1
,2
]}

Yang, Binzhou ^{[3
]}

Ma, Zhongshuang ^{[4
]}

Liu, Guiping ^{[1
,2
]}

Shen, Weigan ^{[1
,5
,6
]}

Zhang, Yu ^{[1
,2
,5
,6
]}

机构：

[1] Yangzhou Univ, Clin Med Coll, Yangzhou, Jiangsu, Peoples R China

[2] Yangzhou Univ, Sch Med, Yangzhou, Jiangsu, Peoples R China

[3] Southwest JiaoTong Univ, Coll Med, Peoples Hosp Chengdu 3, Chengdu, Peoples R China

[4] Yancheng Chengnan Hosp, Dept Rheumatol, Yancheng, Peoples R China

[5] Jiangsu Key Lab Integrated Tradit Chinese & Weste, Yangzhou, Jiangsu, Peoples R China

[6] Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Jiangsu, Peoples R China

来源：

PLOS ONE | 2017年 / 12卷 / 07期

关键词：

NF-KAPPA-B; SYNOVIAL FIBROBLASTS; DISEASE-ACTIVITY; ACTIVATION; PATHOGENESIS; INFLAMMATION; MMP-1; CELL;

D O I：

10.1371/journal.pone.0181003

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Platelet-derived microparticles (PMPs) are closely associated with disease activity in rheumatoid arthritis (RA) and contribute to the inflammatory process. Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) play important roles in the progression of joint destruction. The aim of this study is to demonstrate whether PMPs affect the adhesion and motility of RA-FLSs. Our data indicated that PMPs promoted migration, invasion and adhesion to extracellular matrix (ECM) of RA-FLSs. Further study showed that PMPs up-regulated the expression of matrix metalloproteinase-1 (MMP1) and increased the level of phosphorylation of NF-kappa B (p-NF-kappa B) and Erk (p-Erk) in RA-FLSs. These results suggest that PMPs promote RA-FLSs adhesion and motility presumably by increasing MMP1 via activating Erk-mediated NF-kappa B pathway.

引用

页数：12

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