Pharmacology, Toxicology, and Metabolism of Sennoside A, A Medicinal Plant-Derived Natural Compound

被引：37

作者：

Le, Jiamei ^{[1
,2
]}

Ji, Houlin ^{[1
,3
]}

Zhou, Xiaoxiao ^{[1
,3
]}

Wei, Xindong ^{[1
,4
]}

Chen, Yifan ^{[1
,2
]}

Fu, Yi ^{[1
,2
]}

Ma, Yujie ^{[1
,2
]}

Han, Qiuqin ^{[1
,2
]}

Sun, Yongning ^{[5
]}

Gao, Yueqiu ^{[6
,7
]}

Wu, Hailong ^{[1
,2
]}

机构：

[1] Shanghai Univ Med & Hlth Sci, Zhoupu Hosp, Shanghai, Peoples R China

[2] Shanghai Univ Med & Hlth Sci, Collaborat Innovat Ctr Biomed, Shanghai Key Lab Mol Imaging, Shanghai, Peoples R China

[3] Shanghai Univ Tradit Chinese Med, Shanghai, Peoples R China

[4] Nanjing Univ Chinese Med, Hosp 81, Nanjing, Jiangsu, Peoples R China

[5] Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Dept Cardiol, Shanghai, Peoples R China

[6] Shanghai Univ Tradit Chinese Med, ShuGuang Hosp, Inst Clin Immunol, Cent Lab,Dept Liver Dis, Shanghai, Peoples R China

[7] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Lab Cellular Immun, Shanghai, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷

基金：

上海市自然科学基金; 中国国家自然科学基金;

关键词：

sennoside A; dianthrone glycoside; pharmacology; toxicology; metabolism; ABERRANT CRYPT FOCI; CELL-PROLIFERATION; BACTERIAL TRANSLOCATION; PROSTAGLANDIN E-2; BARRIER FUNCTION; WEIGHT-LOSS; C-JUN; SENNA; COLON; RAT;

D O I：

10.3389/fphar.2021.714586

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sennoside A (SA) is a natural dianthrone glycoside mainly from medicinal plants of Senna and Rhubarb, and used as a folk traditional irritant laxative and slimming health food. Accumulating evidences suggest that SA possesses numerous pharmacological properties, such as laxative, anti-obesity, hypoglycemic, hepatoprotective, anti-fibrotic, anti-inflammatory, anti-tumor, anti-bacterial, anti-fungal, anti-viral, and anti-neurodegenerative activities. These pharmacological effects lay the foundation for its potential application in treating a variety of diseases. However, numerous published studies suggest that a long-term use of SA in large doses may have some adverse effects, including the occurrence of melanosis coli and carcinogenesis of colon cancer, thereby limiting its clinical use. It remains to be established whether SA or its metabolites are responsible for the pharmacological and toxicity effects. In this review, the latest advances in the pharmacology, toxicology, and metabolism of SA were summarizedbased on its biological characteristics and mechanism.

引用

页数：14