Crystal structure based design of functional metal/protein hybrids

被引：13

作者：

Ueno, Takafumi

Yokoi, Norihiko

Abe, Satoshi

Watanabe, Yoshihito ^{[1
]}

机构：

[1] Nagoya Univ, Res Ctr Mat Sci, Nagoya, Aichi 4648602, Japan

[2] Nagoya Univ, Grad Sch Sci, Dept Chem, Nagoya, Aichi 4648602, Japan

[3] Japan Sci & Technol Agcy, PRESTO, Tokyo, Japan

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2007年 / 101卷 / 11-12期

基金：

日本科学技术振兴机构;

关键词：

crystal structure; metal drug; metalloenzyme; biomineralization; hemoprotein; electron transfer;

D O I：

10.1016/j.jinorgbio.2007.06.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Preparation of metal/protein hybrids is growing into important topics in the field of bioinorganic chemistry. X-ray crystal structure analyses of them provide direct information on unique interactions of metal cations or metal cofactors to understand and design enzymatic functions. In this mini review, the authors focus on the recent studies on the metal/protein hybrids concerning crystal structure analyses since 2002 and our related works. The precise structural determination promise us to deeply understand coordination chemistry in protein scaffold and shows intriguing suggestions on rational design and application use for biocatalysts, metal drugs and so on. (C) 2007 Elsevier Inc. All rights reserved.

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页码：1667 / 1675

页数：9

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