Validation of the Restless Legs Syndrome Quality of Life questionnaire

被引:96
作者
Abetz, L [1 ]
Vallow, SM
Kirsch, J
Allen, RP
Washburn, T
Earley, CJ
机构
[1] Mapi Values Ltd, Adelphi Mill, Macclesfield SK10 5JB, Cheshire, England
[2] Janssen Pharmaceutica Inc, Titusville, NJ USA
[3] GlaxoSmithKline, Harlow, Essex, England
[4] Johns Hopkins Univ, Baltimore, MD USA
基金
美国国家卫生研究院;
关键词
health status; quality of life; questionnaire; restless legs syndrome;
D O I
10.1111/j.1524-4733.2005.03010.x
中图分类号
F [经济];
学科分类号
02 ;
摘要
Objectives: The Restless Legs Syndrome Quality of Life questionnaire (RLSQoL) assesses the impact of RLS on daily life, emotional well-being, social life, and work life. This study investigates its validity and reliability. Methods: The RLSQoL was tested in 85 American adults with primary RLS. Patients were also asked to rate symptom severity with the International Restless Legs Scale (patient-reported version) and report on changes in symptoms over the 2-week period. Results: The RLSQoL summary scale score (range: 0-100) demonstrated acceptable internal consistency reliability (Cronbach's alpha = 0.92) and test-retest reliability (intraclass correlation coefficient = 0.84). All items indicated acceptable item-convergent validity. The RLSQoL distinguished between groups with mild, moderate, and severe symptoms (F = 52.22, P < 0.0001). It demonstrated preliminary responsiveness to changes in RLS status over 2 weeks (effect size: improvement, 0.25; deterioration, -0.32), indicating moderate scale changes consistent with the small clinical change over this time. Conclusions: These findings support the conceptual framework of the RLSQoL. It is a valid and reliable measure of the impact of RLS on QoL and is responsive to short-term changes in symptom severity. The RLSQoL appears to be an appropriate tool for trial-based assessments of treatments for RLS.
引用
收藏
页码:157 / 167
页数:11
相关论文
共 25 条
  • [1] ALLEN R, 2002, EUR J NEUROL S2, V9, pP3159
  • [2] Defining the phenotype of the restless legs syndrome (RLS) using age-of-symptom-onset
    Allen, Richard P.
    Earley, Christopher J.
    [J]. SLEEP MEDICINE, 2000, 1 (01) : 11 - 19
  • [3] Restless legs syndrome - A review of clinical and pathophysiologic features
    Allen, RP
    Earley, CJ
    [J]. JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 2001, 18 (02) : 128 - 147
  • [4] MRI measurement of brain iron in patients with restless legs syndrome
    Allen, RP
    Barker, PB
    Wehrl, F
    Song, HK
    Earley, CJ
    [J]. NEUROLOGY, 2001, 56 (02) : 263 - 265
  • [5] [Anonymous], 1997, MAP R WINDOWS MULTIT
  • [6] [Anonymous], 1996, Child Health Questionnaire (CHQ): A User's Manual
  • [7] Validation of the Restless Legs Syndrome quality of life instrument (RLS-QLI): Findings of a consortium of national experts and the RLS Foundation
    Atkinson, MJ
    Allen, RP
    DuChane, J
    Murray, C
    Kushida, C
    Roth, T
    [J]. QUALITY OF LIFE RESEARCH, 2004, 13 (03) : 679 - 693
  • [8] ATKINSON MJ, 2002, MOV DIS SOC 7 INT C
  • [9] Restless legs syndrome in 218 patients: associated disorders
    Banno, Katsuhisa
    Delaive, Kenneth
    Walld, Randy
    Kryger, Meir H.
    [J]. SLEEP MEDICINE, 2000, 1 (03) : 221 - 229
  • [10] Chassany O, 2002, DRUG INF J, V36, P209, DOI 10.1177/009286150203600127