Screening of traditionally used Lebanese herbs for neurological activities

被引：88

作者：

Salah, SM ^{[1
]}

Jäger, AK ^{[1
]}

机构：

[1] Danish Univ Pharmaceut Sci, Dept Med Chem, DK-2100 Copenhagen O, Denmark

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2005年 / 97卷 / 01期

关键词：

acetylcholineseterase; GABA receptor; Lebanese traditional medicine; serotonin transporter;

D O I：

10.1016/j.jep.2004.10.023

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In the recent decades the use of traditional medicine in Lebanon has increased. Aqueous, ethanol and ethyl acetate extracts of seven Lebanese plants that are used traditionally for neurological disorders as Alzheimer's disease, epilepsy and affective disorders as depression were tested for inhibition of acetylcholinesterase and affinity to the GABA(A)-benzodiazepine site and to the serotonin transporter. Ethyl acetate extracts of Salvia triloba, Lavandula officinalis, Origanum syriacum and Artemisia herba-alba exhibited weak activity in the acetylcholinesterase assay. None of the plants were active in the serotonin transporter assay. An ethanolic extract of Artemisia herba-alba had good affinity to the GABA(A)-benzodiazepine receptor site; ethanolic extracts of Melissa officinalis and Salvia triloba had moderate activity. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：145 / 149

页数：5

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