A familial spontaneous epileptic feline strain: A novel model of idiopathic/genetic epilepsy

被引：40

作者：

Kuwabara, Takayuki ^{[1
]}

Hasegawa, Daisuke ^{[1
]}

Ogawa, Fukie ^{[3
]}

Kobayashi, Masanori ^{[1
,4
]}

Fujita, Michio ^{[1
]}

Suzuki, Hiroetsu ^{[2
]}

Matsuki, Naoaki ^{[3
]}

Orima, Hiromitsu ^{[1
]}

机构：

[1] Nippon Vet & Life Sci Univ, Dept Vet Sci, Div Vet Radiol, Tokyo 1808602, Japan

[2] Nippon Vet & Life Sci Univ, Dept Vet Sci, Vet Physiol Lab, Tokyo 1808602, Japan

[3] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Sci, Lab Vet Clin Pathobiol,Bunkyo Ku, Tokyo 1138657, Japan

[4] NCNP, Natl Inst Neurosci, Dept Mol Therapy, Kodaira, Tokyo 1878502, Japan

来源：

EPILEPSY RESEARCH | 2010年 / 92卷 / 01期

关键词：

Animal model; Cat; Spontaneous seizures; Idiopathic epilepsy; Genetic model; LOBE EPILEPSY; PIRIFORM LOBE; KAINIC ACID; SEIZURES; PENTYLENETETRAZOL; HIPPOCAMPUS; NECROSIS; CAT;

D O I：

10.1016/j.eplepsyres.2010.08.010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A spontaneous epileptic model of cats has not been described previously. Recently, we identified familial epileptic cats and investigated their clinical features. These epileptic cats are healthy except for the presence of recurrent seizures that are typically a focal limbic seizure with secondary generalization. Furthermore, generalized seizures were induced by vestibular stimulation in some cats. This spontaneous epileptic cat strain may be a valuable model for idiopathic/genetic epilepsy. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：85 / 88

页数：4

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