Opportunities to Integrate New Approaches in Genetic Toxicology: An ILSI-HESI Workshop Report

被引：15

作者：

Zeiger, Errol ^{[1
]}

Gollapudi, Bhaskar ^{[2
]}

Aardema, Marilyn J. ^{[3
]}

Auerbach, Scott ^{[4
]}

Boverhof, Darrell ^{[2
]}

Custer, Laura ^{[5
]}

Dedon, Peter ^{[6
]}

Honma, Masamitsu ^{[7
]}

Ishida, Seiichi ^{[8
]}

Kasinski, Andrea L. ^{[9
]}

Kim, James H. ^{[10
]}

Manjanatha, Mugimane G. ^{[11
]}

Marlowe, Jennifer ^{[12
]}

Pfuhler, Stefan ^{[13
]}

Pogribny, Igor ^{[11
]}

Slikker, William ^{[11
]}

Stankowski, Leon F., Jr. ^{[14
]}

Tanir, Jennifer Y. ^{[10
]}

Tice, Raymond ^{[4
]}

van Benthem, Jan ^{[15
]}

White, Paul ^{[16
]}

Witt, Kristine L. ^{[4
]}

Thybaud, Veronique ^{[17
]}

机构：

[1] Errol Zeiger Consulting, Chapel Hill, NC 27514 USA

[2] Dow Chem Co USA, Midland, MI 48674 USA

[3] BioReliance Corp, Marilyn Aardema Consulting LLC, Rockville, MD USA

[4] NIEHS, Div Natl Toxicol Program, Res Triangle Pk, NC 27709 USA

[5] Bristol Myers Squibb Co, Dept Genet Toxicol, New York, NY 10154 USA

[6] MIT, Dept Biol Engn, Cambridge, MA 02139 USA

[7] Natl Inst Hlth Sci, Div Genet & Mutagenesis, Tokyo, Japan

[8] Natl Inst Hlth Sci, Div Pharmacol, Tokyo, Japan

[9] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT USA

[10] ILSI Hlth & Environm Sci Inst, Washington, DC USA

[11] US FDA, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA

[12] Novartis, Cambridge, MA USA

[13] Procter & Gamble Co, Cincinnati, OH USA

[14] BioReliance Corp, Rockville, MD USA

[15] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[16] Hlth Canada, Environm Hlth Sci & Res Div, Ottawa, ON K1A 0L2, Canada

[17] Sanofi, Vitry Alfortville Res Ctr, Vitry Sur Seine, France

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 2015年 / 56卷 / 03期

关键词：

genetic toxicity; mutation; epigenetics; genomics;

D O I：

10.1002/em.21923

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Genetic toxicity tests currently used to identify and characterize potential human mutagens and carcinogens rely on measurements of primary DNA damage, gene mutation, and chromosome damage in vitro and in rodents. The International Life Sciences Institute Health and Environmental Sciences Institute (ILSI-HESI) Committee on the Relevance and Follow-up of Positive Results in In Vitro Genetic Toxicity Testing held an April 2012 Workshop in Washington, DC, to consider the impact of new understanding of biology and new technologies on the identification and characterization of genotoxic substances, and to identify new approaches to inform more accurate human risk assessment for genetic and carcinogenic effects. Workshop organizers and speakers were from industry, academe, and government. The Workshop focused on biological effects and technologies that would potentially yield the most useful information for evaluating human risk of genetic damage. Also addressed was the impact that improved understanding of biology and availability of new techniques might have on genetic toxicology practices. Workshop topics included (1) alternative experimental models to improve genetic toxicity testing, (2) Biomarkers of epigenetic changes and their applicability to genetic toxicology, and (3) new technologies and approaches. The ability of these new tests and technologies to be developed into tests to identify and characterize genotoxic agents; to serve as a bridge between in vitro and in vivo rodent, or preferably human, data; or to be used to provide dose response information for quantitative risk assessment was also addressed. A summary of the workshop and links to the scientific presentations are provided. Environ. Mol. Mutagen. 56:277-285, 2015. (c) 2014 Wiley Periodicals, Inc.

引用

页码：277 / 285

页数：9

共 3 条

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