Head injury is associated with tau deposition on PET in MCI and AD patients

被引：11

作者：

Risacher, Shannon L. ^{[1
,2
]}

West, John D. ^{[1
,2
]}

Deardorff, Rachael ^{[1
,2
]}

Gao, Sujuan ^{[2
,3
]}

Farlow, Martin R. ^{[2
,4
]}

Brosch, Jared R. ^{[2
,4
]}

Apostolova, Liana G. ^{[1
,2
,4
]}

McAllister, Thomas W. ^{[5
]}

Wu, Yu-Chien ^{[1
,2
]}

Jagust, William J. ^{[6
,7
]}

Landau, Susan M. ^{[6
,7
]}

Weiner, Michael W. ^{[8
,9
,10
,11
]}

Saykin, Andrew J. ^{[1
,2
,4
]}

机构：

[1] Indiana Univ Sch Med, Dept Radiol & Imaging Sci, Indianapolis, IN 46202 USA

[2] Indiana Univ Sch Med, Indiana Alzheimers Dis Res Ctr, Indianapolis, IN 46202 USA

[3] Indiana Univ Sch Med, Dept Biostat, Indianapolis, IN 46202 USA

[4] Indiana Univ Sch Med, Dept Neurol, Indianapolis, IN 46202 USA

[5] Indiana Univ Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA

[6] Univ Calif Berkeley, HelenWills Neurosci Inst, Berkeley, CA 94720 USA

[7] Lawrence Berkeley Natl Lab, Berkeley, CA USA

[8] Univ Calif San Francisco, Dept Radiol, San Francisco, CA USA

[9] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[10] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA

[11] Dept Vet Affairs Med Ctr, San Francisco, CA USA

来源：

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING | 2021年 / 13卷 / 01期

基金：

美国国家科学基金会; 美国国家卫生研究院; 加拿大健康研究院;

关键词：

Alzheimer's disease; head injury; mild cognitive impairment; tau; traumatic brain injury; 18F]flortaucipir positron emission tomography (PET); TRAUMATIC BRAIN-INJURY; MILD COGNITIVE IMPAIRMENT; ALZHEIMERS; CORE; PROGRESS; NEURODEGENERATION; NEUROPATHOLOGY; DEMENTIA; RISK;

D O I：

10.1002/dad2.12230

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction Head injuries (HI) are a risk factor for dementia, but the underlying etiology is not fully known. Understanding whether tau might mediate this relationship is important. Methods Cognition and tau deposition were compared between 752 individuals with (impaired, n = 302) or without cognitive impairment (CN, n = 450) with amyloid and [F-18]flortaucipir positron emission tomography, HI history information, and cognitive testing from the Alzheimer's Disease Neuroimaging Initiative and the Indiana Memory and Aging Study. Results Sixty-three (38 CN, 25 impaired) reported a history of HI. Higher neuropsychiatric scores and poorer memory were observed in those with a history of HI. Tau was higher in individuals with a history of HI, especially those who experienced a loss of consciousness (LOC). Results were driven by impaired individuals, especially amyloid beta-positive individuals with history of HI with LOC. Discussion These findings suggest biological changes, such as greater tau, are associated with HI in individuals with cognitive impairment. Small effect sizes were observed; thus, further studies should replicate and extend these results.

引用

页数：11

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