Lymphatics in Cardiovascular Physiology

被引：8

作者：

Balasubbramanian, Dakshnapriya ^{[1
,2
]}

Mitchell, Brett M. M. ^{[3
]}

机构：

[1] Boston Childrens Hosp, Vasc Biol Program, Boston, MA 02115 USA

[2] Harvard Med Sch, Dept Surg, Boston, MA 02115 USA

[3] Texas A&M Univ, Coll Med, Dept Med Physiol, Bryan, TX 77807 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2022年 / 12卷 / 08期

关键词：

REVERSE CHOLESTEROL TRANSPORT; DE-NOVO LYMPHANGIOGENESIS; CONGESTIVE-HEART-FAILURE; II-INDUCED HYPERTENSION; CHRONIC ARM LYMPHEDEMA; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; ADIPOSE-TISSUE; BLOOD-PRESSURE; T-CELLS;

D O I：

10.1101/cshperspect.a041173

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The lymphatic vessels play an essential role in maintaining immune and fluid homeostasis and in the transport of dietary lipids. The discovery of lymphatic endothelial cell-specific markers facilitated the visualization and mechanistic analysis of lymphatic vessels over the past two decades. As a result, lymphatic vessels have emerged as a crucial player in the pathogenesis of several cardiovascular diseases, as demonstrated by worsened disease progression caused by perturbations to lymphatic function. In this review, we discuss the major findings on the role of lymphatic vessels in cardiovascular diseases such as hypertension, obesity, atherosclerosis, myocardial infarction, and heart failure.

引用

页数：15

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