Resolving Spliceosomal Malfunctions Advances RNA-Based Therapeutics

被引：1

作者：

Zhang, Zhao ^{[1
]}

Li, Shengli ^{[1
]}

Han, Leng ^{[1
,2
]}

机构：

[1] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Biochem & Mol Biol, Houston, TX 77030 USA

[2] Univ Texas Hlth Sci Ctr Houston, Ctr Precis Hlth, Houston, TX 77030 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2020年 / 26卷 / 02期

关键词：

D O I：

10.1016/j.molmed.2019.11.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spliceosomes comprise small nuclear (sn)RNAs and proteins. Through genome-wide analyses in large-scale tumor samples, recent studies by Shuai et ai., Suzuki et al., and Inoue et ai. have identified recurrent spliceo-somal mutations that induced genome-wide splicing alterations of cancer-related genes to promote malignancy. These discoveries suggest novel RNA-based therapeutics in anticancer treatment.

引用

页码：135 / 137

页数：3

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