Vitamin C Increases the Fecal Fat Excretion by Chitosan in Guinea-pigs, Thereby Reducing Body Weight Gain

被引：15

作者：

Jun, S. C. ^{[1
]}

Jung, E. Y. ^{[2
]}

Kang, D. H. ^{[3
]}

Kim, J. M. ^{[4
]}

Chang, U. J. ^{[1
]}

Suh, H. J. ^{[2
]}

机构：

[1] Dongduk Womens Univ, Dept Food & Nutr, Seoul 136714, South Korea

[2] Korea Univ, Dept Food & Nutr, Seoul 136703, South Korea

[3] Soonchunhyang Univ, Dept Phys Educ, Asan 337880, South Korea

[4] Konkuk Univ, Dept Food Sci & Biotechnol Anim Resources, Seoul 143701, South Korea

来源：

PHYTOTHERAPY RESEARCH | 2010年 / 24卷 / 08期

关键词：

vitamin C; chitosan; guinea-pig; antiobesity; fecal excretion; ASCORBIC-ACID; CHOLESTEROL ABSORPTION; DIETARY-SUPPLEMENTS; LIPID-PEROXIDATION; OXIDATIVE STRESS; DOUBLE-BLIND; BILE-ACID; OVERWEIGHT; OBESITY; PLASMA;

D O I：

10.1002/ptr.2970

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The aims of this study were to investigate the antiobesity properties of chitosan on its own, as well as in the presence of vitamin C, in vivo. Hartley guinea-pigs were divided into Control (normal diet), F-control (high fat diet), Chitosan (high fat diet with 5.0% chitosan) and Chito-vit C (high fat diet with 5.0% chitosan containing 0.5% vitamin C) groups, respectively. The effects of chitosan, both alone and in the presence of vitamin C. on body weight, total fecal weight, fecal composition and plasma lipid level were studied for 5 weeks. The results of this study indicated that the fat-binding and water-holding capacity of chitosan might decrease body weight by reducing the absorption of cholesterol and fat, subsequently increasing total fecal weight, fecal fat excretion and fecal water excretion. Vitamin C increased the fecal fat excretion by chitosan in guinea-pigs, thereby reducing body weight gain. Copyright (C) 2010 John Wiley & Sons, Ltd.

引用

页码：1234 / 1241

页数：8

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