Pyrrolizidine alkaloids act by toxicity to sinusoidal endothelial cells of the liver

被引:0
作者
Ghallab, Ahmed [1 ]
机构
[1] South Valley Univ, Fac Vet Med, Forens Med & Toxicol Dept, Qena, Egypt
关键词
VENOOCCLUSIVE DISEASE; PRIMARY HEPATOCYTES; METABOLISM;
D O I
10.1007/s00204-019-02610-7
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
引用
收藏
页码:3639 / 3640
页数:2
相关论文
共 20 条
[1]   Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations [J].
Albrecht, Wiebke ;
Kappenberg, Franziska ;
Brecklinghaus, Tim ;
Stoeber, Regina ;
Marchan, Rosemarie ;
Zhang, Mian ;
Ebbert, Kristina ;
Kirschner, Hendrik ;
Grinberg, Marianna ;
Leist, Marcel ;
Moritz, Wolfgang ;
Cadenas, Cristina ;
Ghallab, Ahmed ;
Reinders, Joerg ;
Vartak, Nachiket ;
van Thriel, Christoph ;
Golka, Klaus ;
Tolosa, Laia ;
Castell, Jose V. ;
Damm, Georg ;
Seehofer, Daniel ;
Lampen, Alfonso ;
Braeuning, Albert ;
Buhrke, Thorsten ;
Behr, Anne-Cathrin ;
Oberemm, Axel ;
Gu, Xiaolong ;
Kittana, Naim ;
van de Water, Bob ;
Kreiling, Reinhard ;
Fayyaz, Susann ;
van Aerts, Leon ;
Smedsrod, Bard ;
Ellinger-Ziegelbauer, Heidrun ;
Steger-Hartmann, Thomas ;
Gundert-Remy, Ursula ;
Zeigerer, Anja ;
Ullrich, Anett ;
Runge, Dieter ;
Lee, Serene M. L. ;
Schiergens, Tobias S. ;
Kuepfer, Lars ;
Aguayo-Orozco, Alejandro ;
Sachinidis, Agapios ;
Edlund, Karolina ;
Gardner, Iain ;
Rahnenfuehrer, Joerg ;
Hengstler, Jan G. .
ARCHIVES OF TOXICOLOGY, 2019, 93 (06) :1609-1637
[2]   Pyrrolizidine alkaloids - Genotoxicity, metabolism enzymes, metabolic activation, and mechanisms [J].
Fu, PP ;
Xia, QS ;
Lin, G ;
Chou, MW .
DRUG METABOLISM REVIEWS, 2004, 36 (01) :1-55
[3]   Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood [J].
Ghallab, Ahmed ;
Hofmann, Ute ;
Sezgin, Selahaddin ;
Vartak, Nachiket ;
Hassan, Reham ;
Zaza, Ayham ;
Godoy, Patricio ;
Schneider, Kai Markus ;
Guenther, Georgia ;
Ahmed, Yasser A. ;
Abbas, Aya A. ;
Keitel, Verena ;
Kuepfer, Lars ;
Dooley, Steven ;
Lammert, Frank ;
Trautwein, Christian ;
Spiteller, Michael ;
Drasdo, Dirk ;
Hofmann, Alan F. ;
Jansen, Peter L. M. ;
Hengstler, Jan G. ;
Reif, Raymond .
HEPATOLOGY, 2019, 69 (02) :666-683
[4]   Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases [J].
Ghallab, Ahmed ;
Celliere, Geraldine ;
Henkel, Sebastian G. ;
Driesch, Dominik ;
Hoehme, Stefan ;
Hofmann, Ute ;
Zellmer, Sebastian ;
Godoy, Patricio ;
Sachinidis, Agapios ;
Blaszkewicz, Meinolf ;
Reif, Raymond ;
Marchan, Rosemarie ;
Kuepfer, Lars ;
Haeussinger, Dieter ;
Drasdo, Dirk ;
Gebhardt, Rolf ;
Hengstler, Jan G. .
JOURNAL OF HEPATOLOGY, 2016, 64 (04) :860-871
[5]   Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue [J].
Godoy, Patricio ;
Widera, Agata ;
Schmidt-Heck, Wolfgang ;
Campos, Gisela ;
Meyer, Christoph ;
Cadenas, Cristina ;
Reif, Raymond ;
Stoeber, Regina ;
Hammad, Seddik ;
Puetter, Larissa ;
Gianmoena, Kathrin ;
Marchan, Rosemarie ;
Ghallab, Ahmed ;
Edlund, Karolina ;
Nuessler, Andreas ;
Thasler, Wolfgang E. ;
Damm, Georg ;
Seehofer, Daniel ;
Weiss, Thomas S. ;
Dirsch, Olaf ;
Dahmen, Uta ;
Gebhardt, Rolf ;
Chaudhari, Umesh ;
Meganathan, Kesavan ;
Sachinidis, Agapios ;
Kelm, Jens ;
Hofmann, Ute ;
Zahedi, Rene P. ;
Guthke, Reinhard ;
Bluethgen, Nils ;
Dooley, Steven ;
Hengstler, Jan G. .
ARCHIVES OF TOXICOLOGY, 2016, 90 (10) :2513-2529
[6]   Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells [J].
Godoy, Patricio ;
Schmidt-Heck, Wolfgang ;
Natarajan, Karthick ;
Lucendo-Villarin, Baltasar ;
Szkolnicka, Dagmara ;
Asplund, Annika ;
Bjorquist, Petter ;
Widera, Agata ;
Stober, Regina ;
Campos, Gisela ;
Hammad, Seddik ;
Sachinidis, Agapios ;
Chaudhari, Umesh ;
Damm, Georg ;
Weiss, Thomas S. ;
Nuessler, Andreas ;
Synnergren, Jane ;
Edlund, Karolina ;
Kueppers-Munther, Barbara ;
Hay, David C. ;
Hengstler, Jan G. .
JOURNAL OF HEPATOLOGY, 2015, 63 (04) :934-942
[7]   Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME [J].
Godoy, Patricio ;
Hewitt, Nicola J. ;
Albrecht, Ute ;
Andersen, Melvin E. ;
Ansari, Nariman ;
Bhattacharya, Sudin ;
Bode, Johannes Georg ;
Bolleyn, Jennifer ;
Borner, Christoph ;
Boettger, Jan ;
Braeuning, Albert ;
Budinsky, Robert A. ;
Burkhardt, Britta ;
Cameron, Neil R. ;
Camussi, Giovanni ;
Cho, Chong-Su ;
Choi, Yun-Jaie ;
Rowlands, J. Craig ;
Dahmen, Uta ;
Damm, Georg ;
Dirsch, Olaf ;
Teresa Donato, Maria ;
Dong, Jian ;
Dooley, Steven ;
Drasdo, Dirk ;
Eakins, Rowena ;
Ferreira, Karine Sa ;
Fonsato, Valentina ;
Fraczek, Joanna ;
Gebhardt, Rolf ;
Gibson, Andrew ;
Glanemann, Matthias ;
Goldring, Chris E. P. ;
Jose Gomez-Lechon, Maria ;
Groothuis, Geny M. M. ;
Gustavsson, Lena ;
Guyot, Christelle ;
Hallifax, David ;
Hammad, Seddik ;
Hayward, Adam ;
Haeussinger, Dieter ;
Hellerbrand, Claus ;
Hewitt, Philip ;
Hoehme, Stefan ;
Holzhuetter, Hermann-Georg ;
Houston, J. Brian ;
Hrach, Jens ;
Ito, Kiyomi ;
Jaeschke, Hartmut ;
Keitel, Verena .
ARCHIVES OF TOXICOLOGY, 2013, 87 (08) :1315-1530
[8]   Toxicogenomics directory of chemically exposed human hepatocytes [J].
Grinberg, Marianna ;
Stoeber, Regina M. ;
Edlund, Karolina ;
Rempel, Eugen ;
Godoy, Patricio ;
Reif, Raymond ;
Widera, Agata ;
Madjar, Katrin ;
Schmidt-Heck, Wolfgang ;
Marchan, Rosemarie ;
Sachinidis, Agapios ;
Spitkovsky, Dimitry ;
Hescheler, Jurgen ;
Carmo, Helena ;
Arbo, Marcelo D. ;
van de Water, Bob ;
Wink, Steven ;
Vinken, Mathieu ;
Rogiers, Vera ;
Escher, Sylvia ;
Hardy, Barry ;
Mitic, Dragana ;
Myatt, Glenn ;
Waldmann, Tanja ;
Mardinoglu, Adil ;
Damm, Georg ;
Seehofer, Daniel ;
Nuessler, Andreas ;
Weiss, Thomas S. ;
Oberemm, Axel ;
Lampen, Alfons ;
Schaap, Mirjam M. ;
Luijten, Mirjam ;
van Steeg, Harry ;
Thasler, Wolfgang E. ;
Kleinjans, Jos C. S. ;
Stierum, Rob H. ;
Leist, Marcel ;
Rahnenfuehrer, Joerg ;
Hengstler, Jan G. .
ARCHIVES OF TOXICOLOGY, 2014, 88 (12) :2261-2287
[9]   Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes [J].
Gu, Xiaolong ;
Albrecht, Wiebke ;
Edlund, Karolina ;
Kappenberg, Franziska ;
Rahnenfuehrer, Joerg ;
Leist, Marcel ;
Moritz, Wolfgang ;
Godoy, Patricio ;
Cadenas, Cristina ;
Marchan, Rosemarie ;
Brecklinghaus, Tim ;
Tolosa Pardo, Laia ;
Castell, Jose V. ;
Gardner, Iain ;
Han, Bo ;
Hengstler, Jan G. ;
Stoeber, Regina .
ARCHIVES OF TOXICOLOGY, 2018, 92 (12) :3505-3515
[10]   A frequent misinterpretation in current research on liver fibrosis: the vessel in the center of CCl4-induced pseudolobules is a portal vein [J].
Hammad, Seddik ;
Braeuning, Albert ;
Meyer, Christoph ;
Mohamed, Fatma El Zahraa Ammar ;
Hengstler, Jan G. ;
Dooley, Steven .
ARCHIVES OF TOXICOLOGY, 2017, 91 (11) :3689-3692