Synthesis of cross-reactive carbohydrate determinants fragments as tools for in vitro allergy diagnosis

被引：14

作者：

Collot, Mayeul ^{[1
]}

Wilson, Iain B. H. ^{[2
]}

Bublin, Merima ^{[3
]}

Hoffmann-Sommergruber, Karin ^{[3
]}

Mallet, Jean-Maurice ^{[1
]}

机构：

[1] Univ Paris 06, Ecole Normale Super, Dept Chim, CNRS,UMR 7203, F-75005 Paris, France

[2] Univ Nat Resources & Appl Life Sci Vienna, Dept Chem, A-1190 Vienna, Austria

[3] Med Univ Wien, Inst Pathophysiol, A-1090 Vienna, Austria

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2011年 / 19卷 / 03期

关键词：

Allergy; Glycosylation; Biotinylation; Biotin sulfone; Thioglycoside; Cross-reactive carbohydrate determinants; N-LINKED OLIGOSACCHARIDES; DERIVATIVES; EPITOPES; STRATEGY; GLYCANS; ACETALS;

D O I：

10.1016/j.bmc.2010.12.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four biotinylated tri and tetrasaccharide fragments of plant and invertebrate N-glycans were synthesized using methyl tert-butyl phenyl (MBP) thioglycosides donors in order to evaluate their involvement in cross-allergies as cross-reactive carbohydrate determinants (CCDs). Various levels of reactivity to anti-bee and anti-HRP antibodies and with sera from allergic patients were observed when the conjugates were coated on streptavidin microplates. The results showed the potential utility of these xylosylated and fucosylated oligosaccharide fragments in determining CCD antibody epitopes. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1306 / 1320

页数：15

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