Poly(ADP-Ribose)-A Unique Natural Polymer Structural Features, Biological Role and Approaches to the Chemical Synthesis

被引：14

作者：

Drenichev, Mikhail S. ^{[1
]}

Mikhailov, Sergey N. ^{[1
]}

机构：

[1] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2015年 / 34卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

DNA alkylation; modified nucleosides; nucleotide excision and repair; enzyme inhibition; nucleic acid biosynthesis; bioconjugates; DISACCHARIDE NUCLEOSIDES; PARP INHIBITORS; ADP-RIBOSYLATION; BINDING-PROTEINS; LYSINE RESIDUES; IDENTIFICATION; OLIGONUCLEOTIDES; TRIPHOSPHATES; DERIVATIVES; MECHANISM;

D O I：

10.1080/15257770.2014.984073

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Poly(ADP-ribose) (PAR) is a natural polymer, taking part in numerous important cellular processes. Several enzymes are involved in biosynthesis and degradation of PAR. One of them, poly(ADP-ribose)polymerase-1 (PARP-1) is considered to be a perspective target for the design of new drugs, affecting PAR metabolism. The structure of PAR was established by enzymatic hydrolysis and further analysis of the products, but total chemical synthesis of PAR hasn't been described yet. Several approaches have been developed on the way to chemical synthesis of this unique biopolymer.

引用

页码：258 / 276

页数：19

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