Coagulation and wound repair during COVID-19

被引：3

作者：

Menachery, Vineet D. ^{[1
,2
,3
]}

Gralinski, Lisa E. ^{[4
]}

机构：

[1] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

[2] Univ Texas Med Branch, World Reference Ctr Emerging Viruses & Arboviruse, Galveston, TX 77555 USA

[3] Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX 77555 USA

[4] Univ North Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA

来源：

JOURNAL OF HEART AND LUNG TRANSPLANTATION | 2021年 / 40卷 / 10期

关键词：

coronavirus; SARS-CoV-2; COVID-19; coagulation; fibrinolysis; CORONAVIRUS DISEASE 2019; INFLAMMATION;

D O I：

10.1016/j.healun.2021.06.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

While COVID-19 is best known as a respiratory infection, SARS-CoV-2 causes systemic disease manifestations including coagulopathies. Both dysregulated extracellular matrix remodeling pathways and circulating coagulation proteins are hallmarks of severe COVID-19 and often continue after the resolution of acute infection. Coagulation proteins have proven effective as biomarkers for severe disease and anticoagulants are a mainstay of COVID-19 therapeutics in hospitalized patients. While much knowledge has been gained about the role of clotting pathway activation in COVID-19, much remains to be elucidated in this complex network of signaling pathways. J Heart Lung Transplant 2021;40:1076-1081 (c) 2021 International Society for Heart and Lung Transplantation. All rights reserved.

引用

页码：1076 / 1081

页数：6

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