Anti-inflammatory activity of the basolateral fraction of Caco-2 cells exposed to a rosemary supercritical extract

被引：38

作者：

Arranz, E. ^{[1
]}

Mes, J. ^{[2
]}

Wichers, H. J. ^{[2
]}

Jaime, L. ^{[1
]}

Mendiola, J. A. ^{[1
]}

Reglero, G. ^{[1
,3
]}

Santoyo, S. ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Inst Food Sci Res CIAL, CEI UAM CSIC, E-28049 Madrid, Spain

[2] Univ Wageningen & Res Ctr, Food & Biobased Res, NL-6700 AA Wageningen, Netherlands

[3] Univ Autonoma Madrid, Imdea Food Inst, CEI UAM CSIC, E-28049 Madrid, Spain

来源：

JOURNAL OF FUNCTIONAL FOODS | 2015年 / 13卷

关键词：

Rosemary; Bioavailable fraction; Anti-inflammatory activity; Supercritical extraction; ROSMARINUS-OFFICINALIS; CARNOSIC ACID; FLUID EXTRACTS; ANTIOXIDANT; BIOAVAILABILITY; INFLAMMATION; 1,8-CINEOLE; LEAVES; ABSORPTION; MODEL;

D O I：

10.1016/j.jff.2015.01.015

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The anti-inflammatory activity of the basolateral fraction of Caco-2 cells exposed to a rosemary supercritical extract was examined. Uptake of rosemary extract fractions was tested on Caco-2 cell monolayers (2-12 h incubation times) and the quantification of camosic acid and camosol was performed by UPLC-MS/MS. Human macrophages were treated with the basolateral fractions and secretion of TNF-alpha, IL-1 beta, IL-6 and IL-10 was measured by ELISA. The fractions obtained after 8 and 12 h in absorption experiments caused a significant reduction in excretion of the pro-inflammatory cytokines. This reduction in cytokine secretion levels corresponded to the amounts of camosic acid and camosol in the basolateral fractions. Thus, the basolateral fraction of a rosemary supercritical extract showed an important anti-inflammatory activity, providing the basis for increasing the use of supercritical rosemary extracts for the prevention of inflammatory diseases. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：384 / 390

页数：7

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