Oxidation of 1,4-Dihydropyridines and 3,4-Dihydropyrimidin-2(1H)-ones to Substituted Pyridines and Pyrimidinones Using Ca(OCl)2 in Aqueous Media

被引：14

作者：

Tamaddon, Fatemeh ^{[1
]}

Razmi, Zahra ^{[1
]}

机构：

[1] Yazd Univ, Dept Chem, Fac Sci, Yazd 89195741, Iran

来源：

SYNTHETIC COMMUNICATIONS | 2011年 / 41卷 / 04期

关键词：

Biginelli reaction; Ca(OCl)2; 1; 4-dihydropyridines; dihydropyrimidinones; Hantzsch; oxidative dehydrogenation; HANTZSCH 1,4-DIHYDROPYRIDINES; AROMATIZATION; EFFICIENT; MILD;

D O I：

10.1080/00397911003587523

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[image omitted] 1,4-Dihydropyridines and 3,4-dihydropyrimidin-2(1H)-ones obtained from the Hantzsch and Biginelli reactions undergo readily oxidative dehydrogenation by using calcium hypochlorite in very short times. These calcium stimulator drugs were oxidized under reaction conditions next to the in vivo transformations at room temperature.

引用

收藏

页码：485 / 492

页数：8

相关论文

共 26 条

[1]

[Anonymous], 2005, LEHNINGER PRINCIPLES

[2]

Biginelli P., 1893, GAZZ CHIM ITAL, V23, P360

[3] Condensed 1,4-dihydropyridines with various esters and their calcium channel antagonist activities [J].

Bulbul, Bahadir ;

Ozturk, Gokce Sevim ;

Vural, Mert ;

Simsek, Rahime ;

Sarioglu, Yusuf ;

Linden, Anthony ;

Ulgen, Mert ;

Safak, Cihat .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (05) :2052-2058

[4] Aromatization of Hantzsch 1,4-dihydropyridines and 1,3,5-trisubstituted pyrazolines with HIO3 and I2O5 in water [J].

Chai, Lingzhi ;

Zhao, Yankai ;

Sheng, Qiuju ;

Liu, Zhong-Quan .

TETRAHEDRON LETTERS, 2006, 47 (52) :9283-9285

[5] β-Cyclodextrin-Catalyzed Mild Aromatization of Hantzsch 1,4-Dihydropyridines with o-Iodoxybenzoic Acid in Water/Acetone [J].

Chen, Jiang-Min ;

Zeng, Xiao-Mei .

SYNTHETIC COMMUNICATIONS, 2009, 39 (19) :3521-3526

[6] A simple, green and one-pot four-component synthesis of 1,4-dihydropyridines and their aromatization [J].

Das Sharma, Saikat ;

Hazarika, Parasa ;

Konwar, Dilip .

CATALYSIS COMMUNICATIONS, 2008, 9 (05) :709-714

[7] An efficient, metal-free, room temperature aromatization of Hantzsch-1,4-dihydropyridines with urea-hydrogen peroxide adduct, catalyzed by molecular iodine [J].

Filipan-Litvic, Mirela ;

Litvic, Mladen ;

Vinkovic, Vladimir .

TETRAHEDRON, 2008, 64 (24) :5649-5656

[8]

GUENGERICH FP, 1986, J BIOL CHEM, V261, P5051

[9]

HANTZSCH A., 1881, Chem. Ber, V14, P1637, DOI DOI 10.1002/CBER.18810140214

[10] Aromatization of hantzsch 1,4-dihydropyridine with bismuth(III) chloride supported onto wet HZSM-5 zeolite under microwave irradiation in solventless system [J].

Heravi, MM ;

Ghassemzadeh, M .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2005, 180 (02) :347-351