Segregation analysis of idiopathic talipes equinovarus in a Texan population

被引:0
作者
de Andrade, M
Barnholtz, JS
Amos, CI
Lochmiller, C
Scott, A
Risman, M
Hecht, JT
机构
[1] Univ Texas, Sch Med, Houston, TX 77225 USA
[2] Univ Texas, MD Anderson Canc Ctr, Houston, TX USA
[3] Childrens Med Ctr, Dallas, TX 75235 USA
[4] Shriners Hosp Children, Houston Unit, Houston, TX USA
来源
AMERICAN JOURNAL OF MEDICAL GENETICS | 1998年 / 79卷 / 02期
关键词
clubfoot; idiopathic talipes equinovarus; ITEV; birth defect; complex segregation; analysis;
D O I
10.1002/(SICI)1096-8628(19980901)79:2<97::AID-AJMG4>3.0.CO;2-K
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Idiopathic talipes equinovarus (ITEV) is a nonsyndromal congenital anomaly of one or both feet, Casting and surgery are often necessary to obtain correct foot alignment. In spite of treatment, residual deformities of the feet occur and calf muscles may be hypoplastic, The cause of ITEV is unknown but genetic factors have been postulated, Complex segregation analysis was performed on 173 ITEV families including 93 Caucasian and 48 Hispanic families. The recessive mixed model was the best fitting model and no differences were found based on ethnicity. These results confirm previous studies suggesting that there is a genetic component to the development of ITEV, Am, J. Med, Genet. 79:97-102, 1998, (C) 1998 Wiley-Liss, Inc.
引用
收藏
页码:97 / 102
页数:6
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