How genetic variation affects patient response and outcome to therapy for psoriasis

被引：14

作者：

Woolf, Richard T. ^{[1
]}

Smith, Catherine H. ^{[1
]}

机构：

[1] Guys Hosp, St Johns Inst Dermatol, Div Genet & Mol Med, London SE1 9RT, England

来源：

EXPERT REVIEW OF CLINICAL IMMUNOLOGY | 2010年 / 6卷 / 06期

关键词：

biologics; methotrexate; pharmacogenetics; pharmacogenomics; psoriasis; INTERLEUKIN-12/23; MONOCLONAL-ANTIBODY; ENDOTHELIAL GROWTH-FACTOR; GENOME-WIDE ASSOCIATION; D-RECEPTOR POLYMORPHISM; RHEUMATOID-ARTHRITIS; METHOTREXATE THERAPY; SUSCEPTIBILITY GENES; SYSTEMIC TREATMENTS; DOUBLE-BLIND; COAL-TAR;

D O I：

10.1586/ECI.10.74

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Psoriasis is a prevalent chronic inflammatory condition that affects the skin There are many treatments available for psoriasis but they are not universally effective and some have associated toxicities Pharmacogenetics and pharmacogenomics explore the relationship between individual genetic variation and drug effect to allow targeted personalized therapy for patients There has been very limited pharmacogenetic research regarding psoriasis with most limited to small retrospective case control studies looking at single-nucleotide polymorphisms in candidate genes involved in drug pharmacokinetics We review the pharmacogenetic investigation of treatments for psoriasis to date including emerging pharmacogenomic studies In addition we discuss how such genetic data could be incorporated into routine clinical practice and future areas for development in this field

引用

页码：957 / 966

页数：10

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