Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis

被引：35

作者：

Li, Jing ^{[1
]}

机构：

[1] Santa Barbara Cottage Hosp, POB 689, Santa Barbara, CA 93102 USA

来源：

CRITICAL CARE | 2018年 / 22卷

关键词：

Sepsis; Severe sepsis; Sepsis management; Vitamin C; Ascorbic acid; Meta-analysis; ASCORBIC-ACID; SEPTIC SHOCK;

D O I：

10.1186/s13054-018-2191-x

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Two recent publications by Sheikh and Horner and Teng et al. reviewed studies on incorporating vitamin C to treat septic patients; however, a meta-analysis was not offered in either report. This commentary extends both reviews by integrating a meta-analysis and sharing aggregated results. Pooled analyses demonstrated a marked reduction in mortality and duration of vasopressor administration in the group with the use of vitamin C.

引用

页数：4

共 8 条

[1] Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis [J].

Fowler, Alpha A., III ;

Syed, Aamer A. ;

Knowlson, Shelley ;

Sculthorpe, Robin ;

Farthing, Don ;

DeWilde, Christine ;

Farthing, Christine A. ;

Larus, Terri L. ;

Martin, Erika ;

Brophy, Donald F. ;

Gupta, Seema ;

Fisher, Bernard J. ;

Natarajan, Ramesh .

JOURNAL OF TRANSLATIONAL MEDICINE, 2014, 12

[2] Estimating the mean and variance from the median, range, and the size of a sample [J].

Hozo S.P. ;

Djulbegovic B. ;

Hozo I. .

BMC Medical Research Methodology, 5 (1)

[3] Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock A Retrospective Before-After Study [J].

Marik, Paul E. ;

Khangoora, Vikramjit ;

Rivera, Racquel ;

Hooper, Michael H. ;

Catravas, John .

CHEST, 2017, 151 (06) :1229-1238

[4]

Natarajan Ramesh, 2014, J PULM RESP MED, V4, P2, DOI [10.4172/2161-105X.1000214, DOI 10.4172/2161-105X.1000214]

[5] DOES INTRAVENOUS VITAMIN C IMPROVE MORTALITY IN PATIENTS WITH SEVERE SEPSIS? [J].

Sheikh, Mohammed ;

Horner, Daniel .

EMERGENCY MEDICINE JOURNAL, 2018, 35 (04) :272-+

[6] Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration - A randomized, prospective study [J].

Tanaka, H ;

Matsuda, T ;

Miyagantani, Y ;

Yukioka, T ;

Matsuda, H ;

Shimazaki, S .

ARCHIVES OF SURGERY, 2000, 135 (03) :326-331

[7] Vitamin C: The next step in sepsis management? [J].

Teng, J. ;

Pourmand, A. ;

Mazer-Amirshahi, M. .

JOURNAL OF CRITICAL CARE, 2018, 43 :230-234

[8] Effect of high-dose Ascorbic acid on vasopressor's requirement in septic shock [J].

Zabet, Mohadeseh Hosseini ;

Mohammadi, Mostafa ;

Ramezani, Masoud ;

Khalili, Hossein .

JOURNAL OF RESEARCH IN PHARMACY PRACTICE, 2016, 5 (02) :94-100

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