Rats with scopolamine- or MK-801-induced spatial discrimination deficits in the cone field task: animal models for impaired spatial orientation performance

被引：23

作者：

Bouger, PCM ^{[1
]}

van der Staay, FJ ^{[1
]}

机构：

[1] Bayer AG, CNR Res, D-42096 Wuppertal, Germany

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2005年 / 15卷 / 03期

关键词：

cone field; spatial memory; rat; scopolamine; MK-801; dizocilpine;

D O I：

10.1016/j.euroneuro.2004.11.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Spatial cognition appears to be compromised in elderly and in patients suffering from dementia. These deficits are believed to be modelled, at least partly, by the administration of scopolamine or MK-801 in normal adult animals. In order to establish an animal model suited for the evaluation of putative cognition enhancers, we assessed the effects of scopolamine (0.3, 0.5, 0.7 mg kg(-1), i.p.) and MK-801 (0.07, 0.08, 0.09 mg kg(-1), s.c.) in rats trained in the cone field. This task allows the simultaneous investigation of working memory (WM), reference memory (RM) and search strategies. Scopolamine and MK-801 reliably induced spatial cognition deficits in the cone field without inducing behavioural side effects. This task appears to be suited for assessing the effects of putative cognition-enhancing compounds on spatial cognition. (c) 2005 Elsevier B.V. and ECNP. All rights reserved.

引用

页码：331 / 346

页数：16

共 97 条

[1] A behavioral analysis of the spatial learning deficit induced by the NMDA receptor antagonist MK-801 (dizocilpine) in the rat [J].