Lower Blood Pressure-Induced Renal Hypoperfusion Promotes Cisplatin-Induced Nephrotoxicity

被引：7

作者：

Mizuno, Tomohiro ^{[1
,3
]}

Hayashi, Takahiro ^{[4
]}

Shimabukuro, Yuka ^{[1
]}

Murase, Maho ^{[1
]}

Hayashi, Hiroki ^{[3
]}

Ishikawa, Kazuhiro ^{[2
]}

Takahashi, Kazuo ^{[3
]}

Yuzawa, Yukio ^{[3
]}

Yamada, Shigeki ^{[4
]}

Nagamatsu, Tadashi ^{[1
]}

机构：

[1] Meijo Univ, Fac Pharm, Dept Analyt Pharmacol, Nagoya, Aichi 4688503, Japan

[2] Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol & Hosp Pharm, Nagoya, Aichi 4648601, Japan

[3] Fujita Hlth Univ, Sch Med, Dept Nephrol, Toyoake, Aichi 47011, Japan

[4] Fujita Hlth Univ, Sch Med, Dept Clin Pharm, Toyoake, Aichi 47011, Japan

来源：

ONCOLOGY | 2016年 / 90卷 / 06期

关键词：

Cisplatin; Nephrotoxicity; Hypoperfusion; Lower blood pressure; ACUTE KIDNEY INJURY; HIGH-DOSE CISPLATIN; LUNG-CANCER; SHORT HYDRATION; RECEIVING CISPLATIN; UNCHANGED CISPLATIN; VOLUME HYDRATION; CHEMOTHERAPY; FAILURE; SEPSIS;

D O I：

10.1159/000446371

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background and Aims: Cisplatin-induced nephrotoxicity primarily occurs in the proximal tubules, and tubular injuries reduce glomerular filtration rates. Lower blood pressure causes renal hypoperfusion, which promotes ischemic acute kidney injury (AKI). Our study examined the relationship between lower blood pressure-induced renal hypoperfusion and cisplatin-induced nephrotoxicity. Methods: The relationship between cisplatin use and hypoalbuminemia is not clear. This study consisted of Japanese patients who received cisplatin as the first-line chemotherapy at Fujita Health University Hospital from April 2006 to December 2012. Hypoalbuminemia was defined as serum albumin levels <= 3.5 mg/dl. Results: Patients who experienced lower blood pressure during chemotherapy were included in the lower blood pressure group (n = 229), and those who did not were included in the normal blood pressure group (n = 743). Total cisplatin dose in the normal blood pressure and lower blood pressure groups was 58.9 +/- 23.8 and 55.0 +/- 20.4 mg/m(2), respectively. The rate of severe nephrotoxicity was higher and overall survival was shorter in the lower blood pressure group than in the normal blood pressure group. In a multivariable analysis, lower blood pressure significantly correlated with hypoalbuminemia. Conclusions: To prevent ischemic AKI, nutrition and cachexia controlling are important parts of cancer treatment. (C) 2016 S. Karger AG, Basel

引用

页码：313 / 320

页数：8

共 37 条

[1] Current concepts - Normotensive ischemic acute renal failure [J].