Study of anticancer, antimicrobial, immunomodulatory, and silver nanoparticles production by Sidr honey from three different sources

被引：42

作者：

Ghramh, Hamed A. ^{[1
,2
,3
]}

Ibrahim, Essam H. ^{[1
,3
,4
]}

Kilany, Mona ^{[1
,5
]}

机构：

[1] King Khalid Univ, Res Ctr Adv Mat Sci, POB 9004, Abha 61413, Saudi Arabia

[2] King Khalid Univ, Fac Sci, Unit Bee Res & Honey Prod, Abha, Saudi Arabia

[3] King Khalid Univ, Fac Sci, Biol Dept, Abha, Saudi Arabia

[4] Natl Org Res & Control Biol, Blood Prod Qual Control & Res Dept, Cairo, Egypt

[5] NODCAR, Dept Microbiol, Giza, Egypt

来源：

FOOD SCIENCE & NUTRITION | 2020年 / 8卷 / 01期

关键词：

AgNPs; anticancer; antimicrobial; Apis mellifera; Sidr honey; splenic cells; GREEN SYNTHESIS; ANTIBACTERIAL ACTIVITY; STREPTOCOCCUS-MUTANS; IN-VIVO; CANCER; PROLIFERATION; APOPTOSIS; GOLD; INVOLVEMENT; EXTRACT;

D O I：

10.1002/fsn3.1328

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Sidr honey is used as food and medicine in many countries. Study of immunomodulatory and anticancer activity of Sidr honey did not tested before. The aim of this work was to study the anticancer activity and immunomodulatory as well as antimicrobial potential of Sidr honey and its synthesized silver nanoparticles (AgNPs). Sidr honey from three sources (two from Kingdom of Saudi Arabia (KSA) and one from Pakistan) was diluted to 20% and tested for its biological activities and to synthesize AgNPs. The results demonstrated that honeys could produce AgNPs (spherical shape), modulated the growth of normal splenic cells, and have antimicrobial activities. Sidr honey has anticancer activity against HepG2 but not Hela cells. Sidr honey can be used as antimicrobial agent, but can be used as anticancer agent with care as it stimulated cell growth of some lines (e.g., Hala) and inhibited another (e.g., HepG2).

引用

页码：445 / 455

页数：11

共 76 条

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