Tetraploid acute promyelocytic leukemia with double t(15;17) and PML/RARA rearrangements detected by fluorescence in situ hybridization analysis

被引：15
作者：
Oh, SH
Park, TS
Kim, HH
Chang, CL
Lee, EY [1 ]
Son, HC
Chung, JS
Cho, GJ
机构：
[1] Pusan Natl Univ, Dept Lab Med, Pusan 602739, South Korea
[2] Pusan Natl Univ, Dept Internal Med, Pusan 602739, South Korea
来源：
CANCER GENETICS AND CYTOGENETICS | 2003年 / 145卷 / 01期
关键词：
D O I：
10.1016/S0165-4608(03)00035-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Acute promyelocytic leukemia (APL) is characterized by a serious hemorrhagic syndrome, unique morphologic findings, and its response to retinoids. Tetraploidy is a very rare chromosomal abnormality in acute myelocytic leukemia. This report presents a unique case of APL with a tetraploid clone characterized by two t(15; 17) without other chromosomal changes, as well as PML/RARA rearrangements confirmed fluorescence in situ hybridization. The morphology of the blast cells was that of the classic M3 subtype, but the mean blast size exceeded that of control APL cases with diploidy. A chromosomal study revealed a 92,XXXX,t(15;17)(q22;q21)x2 karyotype in all 20 metaphase spreads. Despite all-trans-retinoic acid (ATRA) treatment and chemotherapy, leukemic cells persisted in the blood, and the patient died of an intracranial hemorrhage on the 16th day after admission. (C) 2003 Elsevier Inc. All rights reserved.
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页码：49 / 53
页数：5
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