The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesio interthalamica and medial temporal lobe structures

被引:26
作者
Takahashi, Tsutomu [1 ,4 ]
Suzuki, Michio [1 ,4 ]
Tsunoda, Masahiko [1 ]
Kawamura, Yukiko [6 ,7 ]
Takahashi, Nagahide [6 ,8 ]
Maeno, Nobuhisa [6 ,9 ]
Kawasaki, Yasuhiro [1 ,4 ]
Zhou, Shi-Yu [1 ,4 ,5 ]
Hagino, Hirofumi [1 ]
Niu, Lisha [1 ]
Tsuneki, Hiroshi [2 ]
Kobayashi, Soushi [2 ]
Sasaoka, Toshiyasu [2 ]
Seto, Hikaru [3 ]
Kurachi, Masayoshi [1 ,4 ]
Ozaki, Norio [6 ]
机构
[1] Toyama Univ, Dept Neuropsychiat, Toyama 9300194, Japan
[2] Toyama Univ, Dept Clin Pharmacol, Toyama 9300194, Japan
[3] Toyama Univ, Dept Radiol, Toyama 9300194, Japan
[4] Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Tokyo, Japan
[5] Dalian Med Univ, Dept Psychiat & Med Psychol, Dalian, Peoples R China
[6] Nagoya Univ, Grad Sch Med, Dept Psychiat, Nagoya, Aichi 4648601, Japan
[7] Meijo Univ, Fac Pharm, Div Clin Sci & Neuropsychopharmacol, Nagoya, Aichi 468, Japan
[8] Mt Sinai Sch Med, Lab Mol Neuropsychiat, Dept Psychiat, New York, NY USA
[9] Natl Ctr Geriatr & Gerontol, Dept Brain Sci & Mol Imaging, Natl Inst Longev Sci, Obu, Japan
关键词
adhesio interthalamica; brain-derived neurotrophic factor; dopamine D3 receptor; gene-gene interaction; magnetic resonance imaging; schizophrenia;
D O I
10.1016/j.pnpbp.2008.03.014
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Abnormal neurodevelopment in midline structures such as the adhesio interthalamica (AI), as well as in the medial temporal lobe structures has been implicated in schizophrenia, while its genetic mechanism is unknown. This magnetic resonance imaging study investigated the effect of the genotype combination of the dopamine D3 receptor(DRD3) Ser9Gly and brain-derived neurotrophic factor(BDNF) Val66M et polymorphisms on the AI length and volumetric measures of the medial temporal lobe structures (amygdala, hippocampus, and parahippocampal gyrus) in 33 schizophrenia patients and 29 healthy controls. The subjects with a combination of the Ser/Ser genotype of DRD3 and Met-containing genotypes of BDNF (high-risk combination) had a shorter AI than those without it in the healthy controls, but not in the schizophrenia patients. The subjects carrying the high-risk combination had a smaller posterior hippocampus than those without it lot both diagnostic groups. These genotypic combination effects on brain morphology were not explained by the independent effect of each polymorphism. These findings suggest the effect of gene-gene interaction between the DRD3 and BDNF variations on brain morphology in midline and medial temporal lobe structures, but do not support its specific role in the pathogenesis of schizophrenia. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:1236 / 1242
页数:7
相关论文
共 67 条
[1]  
Andreasen N, 1984, SCALE ASSESSMENT NEG
[2]  
ANDREASEN NC, 1992, ARCH GEN PSYCHIAT, V49, P615
[3]   Antipsychotic-induced tardive dyskinesia and the Ser9Gly polymorphism in the DRD3 gene: A meta analysis [J].
Bakker, PR ;
van Harten, PN ;
van Os, J .
SCHIZOPHRENIA RESEARCH, 2006, 83 (2-3) :185-192
[4]   Brain volumes in relatives of patients with schizophrenia - A meta-analysis [J].
Boos, Heleen B. M. ;
Aleman, Andre ;
Cahn, Wiepke ;
Pol, Hilleke Hulshoff ;
Kahn, Rene S. .
ARCHIVES OF GENERAL PSYCHIATRY, 2007, 64 (03) :297-304
[5]   D2/D3 dopamine receptor binding with [F-18]fallypride in thalamus and cortex of patients with schizophrenia [J].
Buchsbaum, Monte S. ;
Christian, Bradley T. ;
Lehrer, Douglas S. ;
Narayanan, Tanjore K. ;
Shi, Bingzhi ;
Mantil, Joseph ;
Kemether, Eileen ;
Oakes, Terrence R. ;
Mukherjee, Jogeshwar .
SCHIZOPHRENIA RESEARCH, 2006, 85 (1-3) :232-244
[6]   BDNF val66 met allele is associated with reduced hippocampal volume in healthy subjects [J].
Bueller, JA ;
Aftab, M ;
Sen, S ;
Gomez-Hassan, D ;
Burmeister, M ;
Zubieta, JK .
BIOLOGICAL PSYCHIATRY, 2006, 59 (09) :812-815
[7]   EFFECTS OF ELECTRICAL-STIMULATION OF VARIOUS MIDLINE THALAMIC NUCLEI ON THE BILATERAL RELEASE OF DOPAMINE FROM DENDRITES AND NERVE-TERMINALS OF NEURONS IN THE NIGRO-STRIATAL DOPAMINERGIC PATHWAYS [J].
CHERAMY, A ;
ROMO, R ;
GODEHEU, G ;
GLOWINSKI, J .
NEUROSCIENCE LETTERS, 1984, 44 (02) :193-198
[8]   Cavum septum pellucidum and adhesio interthalamica in schizophrenia: an MRI study [J].
de Souza Crippa, Jose Alexandre ;
Zuardi, Antonio Waldo ;
Busatto, Geraldo F. ;
Faria Sanches, Rafael ;
Santos, Antonio Carlos ;
Araujo, David ;
Amaro, Edson ;
Hallak, Jaime Eduardo Cecilio ;
Ng, Virginia ;
McGuire, Philip K. .
EUROPEAN PSYCHIATRY, 2006, 21 (05) :291-299
[9]  
Dubertret C, 1998, AM J MED GENET, V81, P318, DOI 10.1002/(SICI)1096-8628(19980710)81:4<318::AID-AJMG8>3.0.CO
[10]  
2-P