BI-201335 Treatment of Hepatitis C Virus Serine Protease NS3/Non-Structural Protein 4A (NS4A) Inhibitor

被引:0
作者
Vachon, Marie-Louise [1 ,2 ]
机构
[1] Ctr Hosp Univ Quebec, Res Ctr Infect Dis, Quebec City, PQ G1V 4G2, Canada
[2] Univ Laval, CHUL, Quebec City, PQ G1V 4G2, Canada
关键词
Hepatitis C virus; NS3/NS4A inhibitor; Protease inhibitor; BI-201335; HEPATITIS-C-VIRUS; PROTEASE INHIBITOR; PLUS RIBAVIRIN; BOCEPREVIR; TELAPREVIR; RESISTANCE; INFECTION; VX-950;
D O I
10.1358/dof.2012.037.02.1704836
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Chronic hepatitis C affects an estimated 170 million people worldwide and is the leading indication for liver transplantation in the U. S. Until recently, eradication of chronic hepatitis C depended on the combination of pegylated interferon (pegIFN) and ribavirin (RBV). This combination is effective in only 40-50% of patients infected with hepatitis C virus (HCV) genotype 1, and 30-40% of patients co-infected with HIV. It also carries a high burden of side effects, mostly flu-like illness, fatigue, depression and anemia. This low-efficacy/high-toxicity regimen has motivated the search for a more potent treatment with an improved side effect profile. In this context, various therapeutic agents targeting viral enzymes critical to HCV replication have been identified. BI-201335 is a potent and selective HCV serine protease NS3/non-structural protein 4A (NS4A) inhibitor that recently entered phase III clinical trials. In phase II trials, cure rates above 80% were reported for previously untreated patients, with the majority being eligible for shorter treatment duration. Its high potency, once-daily dosing and good safety profile suggest it could be included in future interferon-free direct-acting antiviral combinations.
引用
收藏
页码:99 / 109
页数:11
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