A simple mathematical model of cell clustering by chemotaxis

被引:3
作者
Harris, Paul J. [1 ]
机构
[1] Univ Brighton, Sch Comp Engn & Math, Brighton, E Sussex, England
关键词
Chemotaxis; Cell clustering; Mathematical model; Diffusion equation; Equations of motion; MIGRATION; GRADIENTS; ADHESION;
D O I
10.1016/j.mbs.2017.10.008
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Chemotaxis is the process by which cells and clusters of cells follow chemical signals in order to combine and form larger clusters. The spreading of the chemical signal from any given cell can be modeled using the linear diffusion equation, and the standard equations of motion can be used to determine how a cell, or cluster of cells, moves in response to the chemical signal. The resulting differential equations for the cell locations are integrated through time using the fourth-order Runge-Kutta method. The effect which changing the initial concentration magnitude, diffusion constant and velocity damping parameter has on the shape of the final clusters of cells is investigated and discussed.
引用
收藏
页码:62 / 70
页数:9
相关论文
共 22 条
  • [1] Atkinson K, 1991, INTRO NUMERICAL ANAL
  • [2] Travelling gradients in interacting morphogen systems
    Baker, R. E.
    Maini, P. K.
    [J]. MATHEMATICAL BIOSCIENCES, 2007, 209 (01) : 30 - 50
  • [3] ON A CHEMOTAXIS MODEL WITH SATURATED CHEMOTACTIC FLUX
    Chertock, Alina
    Kurganov, Alexander
    Wang, Xuefeng
    Wu, Yaping
    [J]. KINETIC AND RELATED MODELS, 2012, 5 (01) : 51 - 95
  • [4] Modelling cell motility and chemotaxis with evolving surface finite elements
    Elliott, Charles M.
    Stinner, Bjoern
    Venkataraman, Chandrasekhar
    [J]. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2012, 9 (76) : 3027 - 3044
  • [5] A computational model of chemotaxis-based cell aggregation
    Eyiyurekli, Manolya
    Manley, Prakash
    Lelkes, Peter I.
    Breen, David E.
    [J]. BIOSYSTEMS, 2008, 93 (03) : 226 - 239
  • [6] Global behaviour of a reaction-diffusion system modelling chemotaxis
    Gajewski, H
    Zacharias, K
    [J]. MATHEMATISCHE NACHRICHTEN, 1998, 195 : 77 - 114
  • [7] Controlled aggregation of primary human pancreatic islet cells leads to glucose-responsive pseudoislets comparable to native islets
    Hilderink, Janneke
    Spijker, Siebe
    Carlotti, Francoise
    Lange, Lydia
    Engelse, Marten
    van Blitterswijk, Clemens
    de Koning, Eelco
    Karperien, Marcel
    van Apeldoorn, Aart
    [J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2015, 19 (08) : 1836 - 1846
  • [8] Chemotaxis in the absence of PIP3 gradients
    Hoeller, Oliver
    Kay, Robert R.
    [J]. CURRENT BIOLOGY, 2007, 17 (09) : 813 - 817
  • [9] Tissue surface tensions guide in vitro self-assembly of rodent pancreatic islet cells
    Jia, Dongxuan
    Dajusta, Daniel
    Foty, Ramsey A.
    [J]. DEVELOPMENTAL DYNAMICS, 2007, 236 (08) : 2039 - 2049
  • [10] MODEL FOR CHEMOTAXIS
    KELLER, EF
    SEGEL, LA
    [J]. JOURNAL OF THEORETICAL BIOLOGY, 1971, 30 (02) : 225 - &