Evaluation of Freeze-Dry Chitosan-Gelatin Scaffolds with Olibanum Microspheres Containing Dexamethasone for Bone Tissue Engineering

Bone tissue engineering is now used as an alternative for the treatment of bone-related diseases. In this study, chitosan-gelatin scaffold with olibanum microspheres containing dexamethasone has been produced by the freeze-drying method. SEM and FTIR were used to characterize the scaffolds synthesized. The rate of drug release from these scaffolds was measured by a UV spectrophotometer. The synthesized scaffold was measured in terms of the swelling and degradation rates. In vitro studies were conducted to evaluate bioactivity and the environmental compatibility of the scaffold with an MTT test. A good controlled release was achieved. The bioactivity analysis confirmed the formation of apatite. The results of the MTT test showed that the synthesized scaffold was biocompatible and had an appropriate interaction with the cell. The results showed that the produced scaffold had the properties necessary to regenerate and repair bones.