Single vocal cord irradiation: A competitive treatment strategy in early glottic cancer

被引：30
作者：
Levendag, Peter C. [1 ]
Teguh, David N. [1 ]
Keskin-Cambay, Fatma [1 ]
Al-Mamgani, Abrahim [1 ]
van Rooij, Peter [1 ]
Astreinidou, Eleftheria [1 ]
Kwa, Stefan L. S. [1 ]
Heijmen, Ben [1 ]
Monserez, Dominique A. [1 ]
Osman, Sarah O. S. [1 ]
机构：
[1] Daniel Denhoed Canc Ctr, Erasmus Med Ctr, Dept Radiat Oncol, NL-3075 EA Rotterdam, Netherlands
来源：
RADIOTHERAPY AND ONCOLOGY | 2011年 / 101卷 / 03期
关键词：
Radiotherapy; Single vocal cord irradiation; Laser surgery; Early glottic cancer; Quality of life; Voice handicap index; TRANSORAL LASER MICROSURGERY; SQUAMOUS-CELL CARCINOMA; QUALITY-OF-LIFE; CO2-LASER CORDECTOMY; SURGERY; LARYNGEAL; RADIOTHERAPY;
D O I：
10.1016/j.radonc.2011.05.026
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Introduction: The treatment of choice for early glottic cancer is still being debated; ultimately it relies on the functional outcome. This paper reports on a novel sparing 4D conformal technique for single vocal cord irradiation (SVCI). Material and methods: The records of 164 T1a patients with SCC of the vocal cord, irradiated in the Erasmus MC between 2000 and 2008, were analyzed for local control and overall survival. The quality of life was determined by EORTC H&N35 questionnaires. Also the VHI (voice handicap index), and the TSH (thyroid stimulating hormone) blood levels, were established. On-line image guided SVCI, using cone beam CT or stereotactic radiation therapy (SRT) techniques, were developed. Results: A LC rate at five-years of 93% and a VHI of 12.7 (0-63) was determined. It appeared feasible to irradiate one vocal cord within 1-2 mm accuracy. This way sparing of the contralateral (CL) vocal cord and CL normal tissues, could be achieved. Conclusions: Given the accuracy (1-2 mm) and small volume disease (CTV limited to one vocal cord), for the use of stereotactic RT techniques SVCI with large fraction sizes is currently being investigated in clinic. It is argued that hypofractionated SVCI can be a competitive alternative to laser surgery. (C) 2011 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 101 (2011) 415-419
引用
收藏
页码：415 / 419
页数：5
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