Selective Synthesis of Diverse Heterocycles via Metal-Free Oxidative Coupling of beta-Tetralone and Nitrogen Nucleophiles

被引：14

作者：

Wang, Shuowen ^{[1
]}

Li, Rong ^{[1
]}

Jiang, Shuxin ^{[1
]}

Huang, Huawen ^{[1
]}

Shao, Wen ^{[1
]}

Deng, Guo-Jun ^{[1
,2
]}

机构：

[1] Xiangtan Univ, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environmentally Friendly Chem & Applicat, Minist Educ,Coll Chem, Xiangtan 411105, Peoples R China

[2] South China Univ Technol, Guangdong Prov Key Lab Luminescence Mol Aggregate, Guangzhou 510640, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 08期

基金：

中国国家自然科学基金;

关键词：

beta-tetralones; nitrogen nucleophiles; metal-free; condensation; dehydrogenative aromatization; ONE-POT SYNTHESIS; TANDEM OXIDATION; QUINOXALINE DERIVATIVES; ELEMENTAL SULFUR; PHENOTHIAZINES; KETONES; CYCLOHEXANONES; EFFICIENT; 2-AMINOBENZOTHIAZOLES; 2-AMINOBENZENETHIOLS;

D O I：

10.1002/adsc.202101488

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A mild procedure for the selective preparation of diverse heterocycles (such as quinoxaline, phenazine, phenothiazine, etc.) from beta-tetralones and nitrogen nucleophiles under metal-free conditions has been developed. The iodine reagents played an important role in the selectivity control of condensation and dehydrogenative aromatization cascade processes. These reaction conditions tolerate a wide range of functional groups and apply to oxidation-sensitive nitrogen nucleophiles.

引用

页码：1481 / 1487

页数：7

共 51 条

[1] Izumiphenazines A-C: Isolation and Structure Elucidation of Phenazine Derivatives from Streptomyces sp. IFM 11204 [J].